Tracking brain changes related to Alzheimer's disease
Official title: APOE in the Predisposition to, Protection From, and Prevention of Alzheimer's Disease
Run by Banner Health · NCT04994847 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is trying to see how changes in the brain relate to Alzheimer's disease by tracking older adults who don't have memory problems yet, to help find ways to prevent or slow down the disease.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 50 Years to 90 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Banner Health Academic / other |
| Locations | 1 site (Phoenix, Arizona) |
| Trial ID | NCT04994847 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are cognitively unimpaired adults aged 50 to 90 years old who are in good general health and willing to participate in extensive assessments.
✕Probably not a fit
Patients with significant health issues or medical diseases that may interfere with participation will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to track changes in the brain associated with Alzheimer's disease by collecting a wide range of genetic, cognitive, and biomarker data from cognitively unimpaired older adults. Participants will undergo regular assessments, including blood sample collection, brain imaging (MRI and PET scans), and cognitive evaluations over a period of time. The study focuses on individuals with varying genetic risks for Alzheimer's, particularly those with different APOE genotypes, to identify protective factors and understand the disease's progression. The comprehensive data collected will be used to develop new strategies for preventing or delaying memory and thinking problems linked to Alzheimer's.
Why it matters
Potential benefit: If successful, this study could lead to new approaches for preventing or delaying Alzheimer's disease in at-risk populations.
How similar studies have gone: Other studies focusing on genetic factors and brain imaging in Alzheimer's have shown promise, but this specific approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female age 50 to 90 years old in good general health with no diseases expected to interfere with the study. * Willing to undergo health and cognitive assessments, brain imaging sessions (MRI and PET), and collection and banking of blood with venipuncture and CSF by lumbar puncture for genetic research, biomarker research, and DNA banking. * Determined to be cognitively unimpaired by PI (mechanisms may include verbal interview, participant or study partner reports or specific scores on cognitive assessments) Exclusion Criteria: * Participants with significant health issues or medical diseases that may interfere with participation, including infectious diseases that pose a risk to study personnel. * For PET or MRI: Female participant who is pregnant, lactating, or of childbearing potential without a negative pregnancy test or being two years postmenopausal or surgically sterile. * For MRI: Any contraindication for MRI including, but not limited to, pacemaker, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin, or body. * For CSF collection: Medical or surgical contraindication for lumbar puncture (e.g. on anti-coagulant therapy or had prior lumbar spinal surgery).
Where it's running
-
Banner Alzheimer's Institute
Phoenix, Arizona, United States Recruiting
Study contacts
- Study coordinator: Trisha Walsh
- Email: trisha.walsh@Bannerhealth.com
- Phone: 602-839-6029
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.