Total energy expenditure in healthy Chinese children (7–18) and adults (30–60) measured with doubly labeled water

Total Energy Expenditure in Healthy Chinese Populations: A Nationwide Study Using the Doubly Labelled Water Method

Researchers will measure daily energy expenditure using the doubly labeled water method in healthy Chinese children (7–18) and adults (30–60).

Quick facts

• Study type: Observational
• Enrollment: 240 (estimated)
• Ages: 7 Years to 60 Years
• Sex: All
• Sponsor: Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences (Academic / other)
• Locations: 7 sites (Chongqing, Chongqing Municipality and 6 other locations)
• Trial ID: NCT07178054 on ClinicalTrials.gov

What this trial studies

This nationwide observational project will recruit healthy children aged 7–18 and adults aged 30–60 at sites in Shenzhen, Chongqing, and Haikou to measure total energy expenditure. Participants will receive standardized anthropometric assessments (height, weight, waist and hip circumferences) and have energy expenditure quantified using the doubly labeled water technique over a defined measurement period. Individuals with malnutrition, overweight or obesity, recent acute illness, chronic diseases, musculoskeletal injuries, or disabilities will be excluded to define a healthy reference group. The data will be used to characterize typical energy requirements across age groups and help inform dietary recommendations and public health planning in China.

Who should consider this trial

Good fit: Healthy Chinese children aged 7–18 and healthy adults aged 30–60 without malnutrition, overweight/obesity, recent acute illness, chronic disease, musculoskeletal injuries, or disabilities are ideal candidates.

Not a fit: People under 7 or over 60, and those with overweight/obesity, chronic medical conditions, recent acute illness, or disabilities are unlikely to receive applicable benefit from participation.

Why it matters

Potential benefit: If successful, this work could provide accurate reference values for daily energy needs that help tailor national dietary guidelines and obesity prevention programs.

How similar studies have performed: The doubly labeled water method is the gold standard for measuring total energy expenditure and has been used successfully in national and population studies worldwide, so the approach is well established.

Eligibility criteria

Inclusion Criteria:

* Healthy participants

Exclusion Criteria:

* Exclusion Criteria:

  1. Malnutrient as defined by the Chinese national standards WS/T456-2014 and WS/T 586-2018

     1. Nutritional deficiencies
     2. Overweight
     3. Obesity
  2. Acute illness within the past 7 days

     1. Fever
     2. Diarrhea
     3. Vomiting
  3. Chronic diseases

     1. Cardiovascular diseases
     2. Diabetes mellitus or any form of metabolic disorders

        * Type 1 or Type 2 diabetes
        * Metabolic syndrome
        * Hyperlipidemia
        * Dyslipidemia
     3. Renal diseases

        * Chronic kidney disease
        * Nephrotic syndrome
  4. Musculoskeletal injuries
  5. Disabilities

Where this trial is running

Chongqing, Chongqing Municipality and 6 other locations

• The First Affiliated Hospital of Chongqing Medical University — Chongqing, Chongqing Municipality, China (Not_yet_recruiting)
• Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences — Shenzhen, Guangdong, China (Not_yet_recruiting)
• The First Affiliated Hospital of Hainan Medical University — Haikou, Hainan, China (Not_yet_recruiting)
• The Affiliated Hospital of Inner Mongolia Medical University — Hohhot, Inner Mongolia, China (Not_yet_recruiting)
• The Fourth Affiliated Hospital of China Medical University — Shenyang, Liaoning, China (Recruiting)
• Qingdao Center Hospital of Rehabilitation University — Qingdao, Shandong, China (Not_yet_recruiting)
• Tacheng Prefecture People's Hospital — Tacheng, Xinjiang, China (Not_yet_recruiting)

Study contacts

• Principal investigator: Xueying Zhang, PhD — Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
• Study coordinator: Xueying Zhang, Doctor

Conditions Healthy