Topical treatment for male hair loss using finasteride and minoxidil

Effectiveness and Safety of Topical Finasteride and Minoxidil Combination Compared to Topical Minoxidil for The Treatment of Male Androgenetic Alopecia

This study tests if using a mix of finasteride and minoxidil on the scalp can help men with hair loss grow more hair than just using minoxidil alone.

Quick facts

• Phase: Phase2; Phase3
• Study type: Interventional
• Enrollment: 40 (estimated)
• Ages: 18 Years to 59 Years
• Sex: Male
• Sponsor: Indonesia University (Academic / other)
• Locations: 1 site (Jakarta, Other (Non U.s.))
• Trial ID: NCT05990400 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness and safety of a combination of topical finasteride and minoxidil compared to topical minoxidil alone in treating male androgenetic alopecia. It involves a double-blind, randomized, controlled design with 40 male participants diagnosed with androgenetic alopecia. The primary outcomes measured include hair density and hair diameter, assessed at baseline and every four weeks over a twelve-week period. Additionally, the study monitors any side effects associated with the treatments.

Who should consider this trial

Good fit: Ideal candidates for this study are males aged 18-59 diagnosed with androgenetic alopecia types III-V according to the Hamilton-Norwood criteria.

Not a fit: Patients with other scalp conditions, those using hair growth medications recently, or individuals with a history of adverse reactions to the study medications may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly improve hair growth and density in men suffering from androgenetic alopecia.

How similar studies have performed: Previous studies have shown promising results with similar combinations of topical treatments for hair loss, indicating potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

1. Male aged from 18-59 years diagnosed with androgenic alopecia
2. Androgenic alopecia type III-V according to Hamilton-Norwood criteria
3. Willing to participate in this research by signing the consent form after receiving an explanation from the researcher
4. Willing to not cutting the hair nor coloring the hair during the study

Exclusion Criteria:

1. Diagnosed with other infectious or inflammatory skin disease in the scalp
2. Using oral medications or vitamins that aim to increase the amount of hair in the last 1 month
3. Using topical medication that aim to increase the amount of hair in the last 2 weeks
4. Undergoing cosmetic procedure for AGA therapy such as low-level laser therapy (LLLT) procedures, platelet-rich plasma (PRP) injections, or microneedling within the last 3 months
5. Have sexual disorder such as decreased libido
6. Have a history of allergy or irritant contact dermatitis to the minoxidil and finasteride

Where this trial is running

Jakarta, Other (Non U.s.)

• University Indonesia — Jakarta, Other (Non U.s.), Indonesia (Recruiting)

Study contacts

• Study coordinator: Farah F Lubis, MD

Conditions Androgenetic Alopecia; Finasteride topical; Minoxidil topical; Male androgenetic alopecia