Topical steroid injection for treating esophageal strictures in children
Role of Topical Steroid Injection With Refractory Benign Esophageal Stricture Endoscopic Dilatation in Children
This study is testing if giving steroid injections during an endoscopy can help children with stubborn esophageal strictures feel better and need fewer treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 21 (estimated) |
| Ages | 2 Years to 14 Years |
| Sex | All |
| Sponsor | Al-Azhar University Academic / other |
| Locations | 1 site (Cairo, Select) |
| Trial ID | NCT06514079 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of intralesional steroid injections combined with endoscopic dilatation in children suffering from refractory benign esophageal strictures. The study involves performing upper GI endoscopy to dilate the esophagus and subsequently injecting steroids directly into the stricture under endoscopic guidance. The outcomes are monitored over 12 months, focusing on the frequency of dilatation procedures, the size of dilators used, and improvements in dysphagia scores. The goal is to determine if this combined approach can reduce the recurrence of strictures and improve patient symptoms.
Who should consider this trial
Good fit: Ideal candidates for this study are pediatric patients under 14 years old with refractory benign esophageal strictures who have not previously received steroid injections.
Not a fit: Patients with conditions such as pharyngeal stenosis or tracheo-esophageal fistula, or those who have previously received steroid injections for dilatation, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the need for repeated dilatation procedures and improve swallowing function in affected children.
How similar studies have performed: While the approach of using steroid injections in conjunction with dilatation is not widely tested, similar interventions in other contexts have shown promise, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pediatric patients aged less than 14 years * with refractory benign esophageal strictures * received a dilatation therapy without triamcinolone injections Exclusion Criteria: * failure to pass a guide wire secondary to pharyngeal stenosis * tracheo-esophageal fistula * those who received triamcinolone injections at early dilatation
Where this trial is running
Cairo, Select
- Mohammad Daboos — Cairo, Select, Egypt (Recruiting)
Study contacts
- Principal investigator: Mohammad Daboos — Department of pediatric surgery, faculty of medicine , Al-Azhar University
- Study coordinator: Mohammad Daboos
- Email: daboosmohammad@gmail.com
- Phone: 01007578148
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.