Topical oxygen gel applied around a customized healing collar to improve gum healing after dental implants
Official title: Evaluation of Linear and Volumetric Soft Tissue Changes Following the Application of Topical Oxygen Therapy Around Customized Healing Collars: Case Series
Run by Cairo University · NCT07384403 · Data updated 2026-11-12
This will test whether applying topical oxygen gel around a customized healing collar helps improve soft tissue shape and volume in adults receiving dental implants.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 6 (estimated) |
| Sponsor | Cairo University Academic / other |
| Drugs / interventions | Chemotherapy |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | July 2026 |
| Study ends | September 2026 |
| Registry record updated | February 3, 2026 |
| Trial ID | NCT07384403 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 21 or older in good general health who are indicated for customized healing collar placement after second-stage implant surgery, willing to consent and attend follow-ups, and without systemic or medication-related impairments to healing.
✕Probably not a fit
Patients who smoke, have systemic diseases or medications that impair healing, are pregnant or lactating, or have had recent chemotherapy or radiotherapy are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants who have osseointegrated implants and are scheduled for second-stage surgery will receive a standardized preoperative assessment and oral hygiene optimization. At implant exposure, a customized healing abutment will be placed and topical oxygen therapy (oxygen gel) will be applied around the collar according to a defined protocol. Linear and volumetric changes in peri-implant soft tissue will be measured over follow-up visits to compare healing with the oxygen therapy approach. Excluded are patients with systemic conditions or behaviors that impair healing, such as smoking or recent chemotherapy/radiotherapy.
Why it matters
Potential benefit: If successful, this approach could improve peri-implant soft tissue contour and volume, speed soft tissue regeneration, and enhance long-term esthetic outcomes.
How similar studies have gone: Topical oxygen therapy has shown promise in promoting wound healing and tissue regeneration in other settings, but its specific application with customized implant healing abutments in oral implantology remains relatively novel with limited direct clinical data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 21 years and above. * Indicated for customized healing collar placement after second-stage surgery. * Good general health. * Able and willing to provide written informed consent. * Committed to follow-up visits. Exclusion Criteria: * Individuals below 21 years old. * Systemic diseases affecting healing. * Smokers/tobacco users. * Pregnant/lactating women. * Medications affecting soft tissue healing. * Chemotherapy/radiotherapy patients.
Where it's running
-
Cairo university
Cairo, Egypt Recruiting
Study contacts
- Principal investigator: Mulhem ahmed — Cairo University
- Study coordinator: Mulhem ahmed, bachelor
- Email: mulhem.ahmad@dentistry.cu.edu.eg
- Phone: 00201050202633
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.