Topical bromelain versus topical corticosteroid for oral lichen planus

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 2 interventional trial compares three topical regimens for symptomatic oral lichen planus: 0.1% triamcinolone acetonide in Orabase, topical bromelain, and a combination of bromelain plus triamcinolone in Orabase. Eligible participants without other oral lesions or recent systemic/topical immunosuppressive treatment will receive one of the three preparations and be followed for lesion healing, pain/symptom changes, and local adverse effects. Treatments are applied to the oral mucosa and clinical response and safety will be recorded over the treatment period. The goal is to determine whether bromelain alone or as an adjunct can provide effective, well-tolerated topical therapy compared with the standard steroid preparation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients suffering from symptomatic OLP
* Patients free from any visible oral lesions other than OLP.
* Patients who agreed to take the supplied interventions.
* Patient who will agree to participate in the study.
* Patients who will accept to sign the informed consent.

Exclusion Criteria:

* Patients suffering from any systemic disease.
* Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks.
* Treatment with any oral topical medications for at least four weeks prior to the study.
* Pregnant and lactating mothers.

Where it's running

• Cairo University
  Cairo, Cairo Governorate, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.