Tonlamarsen to lower blood pressure after a hospital stay for acute severe hypertension.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a Phase 2, randomized, placebo-controlled trial of the investigational antisense agent tonlamarsen in adults recently hospitalized for acute severe hypertension. Participants receive approximately three monthly doses and attend about six clinic visits for blood pressure checks, angiotensinogen (AGT) measurements, safety labs, and follow-up. The main outcomes are changes in plasma AGT levels and clinic blood pressure over time, with continuous monitoring for adverse events and tolerability. The trial enrolls adults with established cardiovascular or renal comorbidities who have elevated systolic blood pressure after discharge.

Why it matters

Who can join: the full rules

Key Inclusion Criteria:

* Age 18 or older, body weight ≥ 50 kg with BMI ≤45.0 kg/m2
* Ready for discharge or recently discharged from the hospital to home (within the past 7 days) during which evaluation and/or treatment of acute severe hypertension (documented SBP ≥ 180 mmHg and/or DBP ≥ 110 mmHg) occurred, as measured by a healthcare provider (HCP) within the 24 hours preceding hospitalization or during the initial 24 hours of hospitalization
* At Screening and Randomization visit, average resting office systolic blood pressure ≥ 145 mmHg
* Presence of established cardiovascular or renal disease

Key Exclusion Criteria:

* Has known history of secondary hypertension
* Any malignancy requiring treatment within 5 years (except for basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix that has been successfully treated)
* Has abnormal thyroid function with clinical significance
* Recent hospitalization for stroke, myocardial infarction or coronary revascularization within 30 days prior to screening
* History of and/or obvious clinical signs or symptoms of cirrhosis or other significant liver disease
* Alanine aminotransferase or aspartate aminotransferase \>2 x upper limit of normal
* Most recent hospitalization was for non-cardiovascular or non-renal conditions

Where it's running

• Western Nephrology and Metabolic Bone Disease, PC - Arvada
  Arvada, Colorado, United States Recruiting
• Homestead Associates in Research
  Homestead, Florida, United States Recruiting
• Progressive Medical Research
  Port Orange, Florida, United States Recruiting
• Eagle Clinical Research
  Chicago, Illinois, United States Recruiting
• Henry Ford Hospital
  Detroit, Michigan, United States Recruiting
• Research Innovations, LLC
  Beavercreek, Ohio, United States Recruiting

Study contacts

• Study coordinator: Kardigan Clinical Study Information Team
• Email: clinicaltrials@kardigan.bio
• Phone: +1-877-310-5135

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.