TOF3D mechanomyograph for monitoring neuromuscular block during anesthesia.
Official title: The TOF3D Mechanomyograph. Evaluation of a New Device for Assessment of the Neuromuscular Block.
Run by Klinikum Hersfeld-Rotenburg · NCT07371377 · Data updated 2026-11-12
This project will test whether the TOF3D mechanomyograph measures muscle relaxation more precisely than standard acceleromyography in people having surgery under general anesthesia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Klinikum Hersfeld-Rotenburg Academic / other |
| Locations | 1 site (Bad Hersfeld) |
| Status | Recruiting |
| Started | January 9, 2026 |
| Main results expected | December 2026 |
| Study ends | July 2027 |
| Registry record updated | January 27, 2026 |
| Trial ID | NCT07371377 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for surgery under general anesthesia who will receive neuromuscular blocking agents and who do not have pregnancy, known neuromuscular disorders, a difficult airway, or elevated aspiration risk.
✕Probably not a fit
People who are pregnant, have neuromuscular disorders, have a known or anticipated difficult airway, or are not receiving neuromuscular blockers would not be eligible and would not benefit directly from this device.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial compares a new mechanomyography device (TOF3D) with standard acceleromyography in patients receiving neuromuscular blocking drugs during general anesthesia. Part 1 directly compares mechanomyograph readings to acceleromyograph readings, while Part 2 compares two mechanomyography modes that use different stimulation patterns. Investigators will record the time course of the neuromuscular block intraoperatively. Patients with anticipated difficult airway, increased aspiration risk, pregnancy, or neuromuscular disorders are excluded.
Why it matters
Potential benefit: If successful, the device could provide more precise monitoring of muscle relaxation and help reduce the risk of residual paralysis after anesthesia.
How similar studies have gone: Mechanomyography has primarily been used in experimental settings and some reports suggest greater precision than acceleromyography, but direct clinical comparisons remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients scheduled for surgery requiring general anesthesia with neuromuscular blocking agents Exclusion Criteria: * anticipated or known difficult airway * increased risk for aspiration * pregnancy * neuromuscular disorders
Where it's running
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Department of Anesthesia and Intensive Care Medicine
Bad Hersfeld, Germany Recruiting
Study contacts
- Study coordinator: Stefan Soltesz, Professor
- Email: stefan.soltesz@klinikum-hef.de
- Phone: 0049 6621 88 922775
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.