Clinical trial Recruiting at 1 site Observational Ages 12 to 40

Timing of nerve-freezing pain relief after Nuss repair for pectus excavatum

Official title: How Long Does it Take for Percutaneous Intercostal Cryoneuromodulation to Produce Cryoanalgesia? A Prospective Observational Study.

Run by Papa Giovanni XXIII Hospital · NCT07081620 · Data updated 2026-11-12

We will test how quickly a nerve-freezing procedure (percutaneous intercostal cryoneurolysis) reduces chest skin sensitivity in people having Nuss surgery for pectus excavatum.

More Pectus Excavatum trials

Quick facts

Study typeObservational
Ages12 Years to 40 Years
SexAll
Enrollment20 (estimated)
SponsorPapa Giovanni XXIII Hospital
Academic / other
Locations1 site (Bergamo, BG)
StatusRecruiting
StartedJune 7, 2025
Main results expectedSeptember 2026
Study endsNovember 2026
Registry record updatedJuly 23, 2025
Trial IDNCT07081620 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are people scheduled for Nuss repair for pectus excavatum who will receive preoperative percutaneous intercostal cryoneurolysis and can attend the planned follow-up sensory exams.

Probably not a fit

People who do not receive cryoneurolysis, who have preexisting sensory neuropathy, or who undergo different chest procedures are unlikely to benefit from this study's findings.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Percutaneous intercostal cryoneurolysis is used before Nuss repair to reduce acute postoperative chest pain, but the onset of sensory change is unclear. This observational study will follow patients who receive preoperative cryoneurolysis and perform daily physical exams measuring chest skin sensitivity to soft touch, cold (4°C), and heat (40°C). Examinations will be done on the days following the procedure to document when sensory loss or reduction appears and how it evolves. The study is single-center at Papa Giovanni XXIII Hospital in Bergamo and involves no additional interventions beyond standard care and sensory testing.

Why it matters

Potential benefit: If successful, the results could help clinicians time pain-management strategies and potentially reduce opioid use after Nuss repair.

How similar studies have gone: Previous cryoneurolysis studies have shown reduced postoperative pain after thoracic procedures including Nuss repair, but the exact time course of sensory change has not been well defined.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients who are undergoing preoperative percutaneous intercostal cryoneurolysis for pectus excavatum surgery

Exclusion Criteria:

* failure to obtain consent

Where it's running

  • Papa Giovanni XXIII Hospital
    Bergamo, Bg, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.