Timing of nerve-freezing pain relief after Nuss repair for pectus excavatum
Official title: How Long Does it Take for Percutaneous Intercostal Cryoneuromodulation to Produce Cryoanalgesia? A Prospective Observational Study.
Run by Papa Giovanni XXIII Hospital · NCT07081620 · Data updated 2026-11-12
We will test how quickly a nerve-freezing procedure (percutaneous intercostal cryoneurolysis) reduces chest skin sensitivity in people having Nuss surgery for pectus excavatum.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 12 Years to 40 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Papa Giovanni XXIII Hospital Academic / other |
| Locations | 1 site (Bergamo, BG) |
| Status | Recruiting |
| Started | June 7, 2025 |
| Main results expected | September 2026 |
| Study ends | November 2026 |
| Registry record updated | July 23, 2025 |
| Trial ID | NCT07081620 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people scheduled for Nuss repair for pectus excavatum who will receive preoperative percutaneous intercostal cryoneurolysis and can attend the planned follow-up sensory exams.
✕Probably not a fit
People who do not receive cryoneurolysis, who have preexisting sensory neuropathy, or who undergo different chest procedures are unlikely to benefit from this study's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Percutaneous intercostal cryoneurolysis is used before Nuss repair to reduce acute postoperative chest pain, but the onset of sensory change is unclear. This observational study will follow patients who receive preoperative cryoneurolysis and perform daily physical exams measuring chest skin sensitivity to soft touch, cold (4°C), and heat (40°C). Examinations will be done on the days following the procedure to document when sensory loss or reduction appears and how it evolves. The study is single-center at Papa Giovanni XXIII Hospital in Bergamo and involves no additional interventions beyond standard care and sensory testing.
Why it matters
Potential benefit: If successful, the results could help clinicians time pain-management strategies and potentially reduce opioid use after Nuss repair.
How similar studies have gone: Previous cryoneurolysis studies have shown reduced postoperative pain after thoracic procedures including Nuss repair, but the exact time course of sensory change has not been well defined.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who are undergoing preoperative percutaneous intercostal cryoneurolysis for pectus excavatum surgery Exclusion Criteria: * failure to obtain consent
Where it's running
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Papa Giovanni XXIII Hospital
Bergamo, Bg, Italy Recruiting
Study contacts
- Study coordinator: Stefano Mariconti, MD
- Email: smariconti@asst-pg23.it
- Phone: 00390358347
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.