Timing of levonorgestrel IUD placement and ovarian cysts

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In a prospective observational design, women aged 18–45 receiving a levonorgestrel IUD will be grouped by menstrual subphase at the time of insertion (early/late follicular and early/late luteal). Participants will have a baseline gynecologic exam, transvaginal ultrasound, and hormone profile, then scheduled ultrasound follow-ups at 0, 3, 6, and 12 months to document cyst occurrence, size, and structure. The study also records bleeding patterns, pain, and other adverse events without randomization or blinding. Statistical analysis will use chi-square or Fisher tests with effect sizes reported and standard p-value thresholds.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Reproductive age: 18-45 years
* Patients with indications for LNG-IUD (levonorgestrel-containing intrauterine device) insertion (abnormal uterine bleeding, menorrhagia, dysmenorrhea, endometriosis, adenomyosis, hormonally induced dysfunctional uterine bleeding, endometrial protection in women receiving postmenopausal hormone replacement therapy, and endouterine hyperplasia without atypia)
* Patients without contraindications for LNG-IUD (no suspected pregnancy, no serious uterine anomalies (Müllerian anomalies), no active pelvic infection, no history of serious liver disease or breast cancer, and no anatomical or clinical contraindications to IUD insertion) will be included.
* They must not have used oral contraceptives for at least 3 months.
* The previous IUD must have been removed at least 1 year prior.
* Those who signed the informed consent form and agreed to participate voluntarily will be included in the study.
* Those who have not used steroidal anti-inflammatory drugs within 24 hours of insertion of a levonorgestrel-containing IUD will be included in the study.

Exclusion Criteria:

* Pregnancy history or current pregnancy
* Patients using hormone therapy
* Patients with adnexal masses
* Patients with severe systemic diseases (uncontrolled diabetes, advanced cardiovascular disease, active malignancies (especially hormone-sensitive ones), advanced liver or kidney failure, systemic connective tissue diseases)
* Patients with contraindications to the levonorgestrel IUD (suspected pregnancy, severe uterine anomaly, active pelvic infection, severe liver disease, or a history of breast cancer, anatomical or clinical obstacles to intrauterine device insertion)
* Patients with psychological disabilities
* Patients who refuse to sign the informed consent form
* Patients who cannot be followed up will not be included in the study.

Where it's running

• SBÜ Gaziosmanpaşa Training and Research Hospital
  Gaziosmanpaşa, Outside of the US, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: havva betül bacak, md — SBÜ Gaziosmanpaşa Training and Research Hospital
• Study coordinator: ecenur çelikoğlu, md
• Email: ecenucelikoglu14@gmail.com
• Phone: +905385492848

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pain and period life: does menstrual cycle or menopause change pain during root canals?

  This study will see if pain during a root canal varies with menstrual cycle phase or menopausal status in adult patients.

  Recruiting Nigde Omer Halisdemir University · Niğde · NCT07850167

• Menstrual cycle symptoms and female health

  This study will observe how common menstrual symptoms and related conditions appear in young adult women who have regular periods, to better understand their frequency and impact.

  Recruiting Universidad Rey Juan Carlos · Madrid · NCT07699224

• Ovarian Reserve After Cystectomy for Endometriotic vs. Non-Endometriotic Cysts

  This study tests how laparoscopic removal of ovarian cysts affects ovarian reserve in women with endometriotic cysts compared to benign/non-endometriotic cysts.

  Recruiting Benha University · Banhā, Qalyubia Governorate · NCT07686783

• How the menstrual cycle and birth control affect strength and performance in athletes

  This study tests how natural menstrual cycle phases and monophasic birth control influence strength, hydration, and energy balance in female athletes.

  Recruiting Faculdade de Motricidade Humana · Cruz Quebrada, Oeiras · NCT07591818

• Menstrual cycle effects on optic nerve sheath diameter during laparoscopic gynecologic surgery

  This study will try to see if menstrual cycle phase changes the optic nerve sheath size and affects postoperative nausea, vomiting, and thinking in women having elective laparoscopic gynecologic surgery.

  Recruiting Konya City Hospital · Konya · NCT07539831

• Phenylalanine needs during the follicular and luteal menstrual phases

  We will test how much phenylalanine healthy menstruating women (ages 20–35) need during the follicular versus luteal phase of the menstrual cycle.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07481201

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.