Timing of clear-fluid fasting before a liver transplant
"Duration of Preoperative Clear Fluids Fasting in Patients Undergoing Liver Transplant. A Prospective Observational Study: the "Timbarc-1" a Pilot Study"
We will record how long people having an elective liver transplant fast from clear fluids and see if longer fasting links to changes in blood pressure, heart rate, blood glucose, lactate, or acid–base balance during anesthesia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Medical University of Warsaw Academic / other |
| Locations | 1 site (Warsaw, Warszawa) |
| Trial ID | NCT07288281 on ClinicalTrials.gov |
What this trial studies
This prospective observational project will enroll adults scheduled for elective liver transplant at the University Clinical Centre of the Medical University of Warsaw. Researchers will record each patient's reported duration of preoperative clear-fluid fasting and collect hemodynamic (blood pressure, heart rate) and metabolic (blood glucose, lactate, acid–base) measurements at defined anesthesia and transplant phases. Patients unable to provide reliable fasting information because of severe hepatic encephalopathy or cognitive impairment are excluded. No interventions will be assigned; the analysis will focus on associations between fasting duration and intraoperative physiologic changes.
Who should consider this trial
Good fit: Adults scheduled for an elective liver transplant at the participating center who can give informed consent and report their clear-fluid fasting time.
Not a fit: Patients undergoing urgent or emergency transplants or those with severe hepatic encephalopathy or cognitive impairment who cannot report fasting times are unlikely to benefit from participation.
Why it matters
Potential benefit: If a relationship is found, the results could help personalize clear-fluid fasting timing to reduce metabolic or hemodynamic instability during liver transplant anesthesia.
How similar studies have performed: Shorter clear-fluid fasting has been shown safe and sometimes beneficial in general surgical populations, but evidence specific to liver transplant recipients is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients scheduled for elective liver transplant Exclusion Criteria: * patients unable to give detailed answer on clear fluid fasting due to severe hepatic encephalopathy or cognitive impairment * lack of written informed consent
Where this trial is running
Warsaw, Warszawa
- University Clinical Centre of Medical University of Warsaw — Warsaw, Warszawa, Poland (Recruiting)
Study contacts
- Study coordinator: Paula Dudek, Medical Doctor
- Email: paula.dudek@wum.edu.pl
- Phone: +49225992001
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.