Timing of Breathing Trials for Patients on Ventilators
Impact of Spontaneous Breathing Trial Timing on Outcomes in Mechanically Ventilated Adult Patients
This study tests whether doing breathing trials earlier in the morning helps adult patients on ventilators recover faster and leave the ICU sooner compared to doing them later in the morning.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 348 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | Rush University Medical Center Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Trial ID | NCT06561295 on ClinicalTrials.gov |
What this trial studies
This study investigates how the timing of Spontaneous Breathing Trials (SBTs) influences recovery in adult patients on mechanical ventilation in the ICU. It compares outcomes between patients who undergo SBTs early in the morning versus those who have them later in the morning. The goal is to determine the optimal timing for these trials to minimize the duration of mechanical ventilation and improve overall recovery metrics, including ICU stay and hospital discharge times.
Who should consider this trial
Good fit: Ideal candidates are adults aged 21 years or older who have been on mechanical ventilation for more than 48 hours and have completed at least one SBT.
Not a fit: Patients intubated for surgical procedures, those with a tracheostomy, or receiving VV-ECMO may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved recovery times and reduced reliance on mechanical ventilation for ICU patients.
How similar studies have performed: While there is variability in SBT timing practices, this specific comparison of early versus later morning trials has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 21 years or older. * Patients who have been on mechanical ventilation for more than 48 hours. * Patients who have completed at least one SBT. Exclusion Criteria: * Patients intubated at other hospitals. * Patients intubated for surgical or interventional procedures. * Patients receiving venovenous extracorporeal membrane oxygenation (VV-ECMO). * Patients with a tracheostomy.
Where this trial is running
Chicago, Illinois
- Rush University Medical Center — Chicago, Illinois, United States (Recruiting)
Study contacts
- Principal investigator: JIE LI, PhD — Rush University
- Study coordinator: JIE LI, PhD
- Email: jie_li@rush.edu
- Phone: 3125634643
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.