Clinical trial Recruiting at 1 site Interventional Ages 21 and up

Timing of Breathing Trials for Patients on Ventilators

Official title: Impact of Spontaneous Breathing Trial Timing on Outcomes in Mechanically Ventilated Adult Patients

Run by Rush University Medical Center · NCT06561295 · Data updated 2026-11-12

This study tests whether doing breathing trials earlier in the morning helps adult patients on ventilators recover faster and leave the ICU sooner compared to doing them later in the morning.

Quick facts

Study typeInterventional
Ages21 Years and up
SexAll
Enrollment348 (estimated)
SponsorRush University Medical Center
Academic / other
Locations1 site (Chicago, Illinois)
StatusRecruiting
StartedSeptember 17, 2024
Main results expectedDecember 30, 2026
Study endsFebruary 28, 2027
Registry record updatedSeptember 30, 2026
Trial IDNCT06561295 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 21 years or older who have been on mechanical ventilation for more than 48 hours and have completed at least one SBT.

Probably not a fit

Patients intubated for surgical procedures, those with a tracheostomy, or receiving VV-ECMO may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how the timing of Spontaneous Breathing Trials (SBTs) influences recovery in adult patients on mechanical ventilation in the ICU. It compares outcomes between patients who undergo SBTs early in the morning versus those who have them later in the morning. The goal is to determine the optimal timing for these trials to minimize the duration of mechanical ventilation and improve overall recovery metrics, including ICU stay and hospital discharge times.

Why it matters

Potential benefit: If successful, this study could lead to improved recovery times and reduced reliance on mechanical ventilation for ICU patients.

How similar studies have gone: While there is variability in SBT timing practices, this specific comparison of early versus later morning trials has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults aged 21 years or older.
* Patients who have been on mechanical ventilation for more than 48 hours.
* Patients who have completed at least one SBT.

Exclusion Criteria:

* Patients intubated at other hospitals.
* Patients intubated for surgical or interventional procedures.
* Patients receiving venovenous extracorporeal membrane oxygenation (VV-ECMO).
* Patients with a tracheostomy.

Where it's running

  • Rush University Medical Center
    Chicago, Illinois, United States
    Recruiting

Study contacts

  • Principal investigator: JIE LI, PhD — Rush University
  • Study coordinator: JIE LI, PhD
  • Email: jie_li@rush.edu
  • Phone: 3125634643

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.