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Clinical trial Recruiting at 2 sites Interventional Ages 18 and up

Time-restricted eating for adult survivors of childhood cancer

Official title: Decreasing Cardiometabolic Risk in Childhood Cancer Survivors: The STRENGTH (Survivors Engaged in Time-Restricted EatiNG After THerapy) Study

Run by Memorial Sloan Kettering Cancer Center · NCT07009288 · Data updated 2026-11-12

This study will test whether time-restricted eating combined with regular coaching helps adult survivors of childhood cancer lose weight and lower heart and metabolic risk compared with standard education and monthly weigh-ins.

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Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment300 (estimated)
SponsorMemorial Sloan Kettering Cancer Center
Academic / other
Locations4 sites (New York, New York and 3 other locations)
StatusRecruiting
StartedMay 27, 2025
Main results expectedMay 1, 2030
Study endsMay 1, 2031
Registry record updatedSeptember 3, 2026
Trial IDNCT07009288 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults (age ≥18) who are enrolled in the Childhood Cancer Survivor Study, have a BMI ≥25 kg/m2, are not pregnant, have stable medications and weight, and can access the internet (study can loan a device if needed).

Probably not a fit

People who live outside the United States, do not speak English, already keep an eating window under 12 hours, use insulin or GLP-1 agonists, have type 1 diabetes, or are enrolled in another formal weight-loss program are unlikely to benefit from or be eligible for this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adult survivors enrolled in the Childhood Cancer Survivor Study who meet weight criteria will be assigned to either a program of time-restricted eating plus motivational sessions with regular calls from a trained health coach or to usual care consisting of educational materials and monthly weight measurements. The intervention uses scheduled daily eating windows (TRE) alongside behavioral coaching and remote contacts to support adherence. Outcomes include weight change and cardiometabolic risk measures collected through monthly weights and participant questionnaires. The study does not provide cancer treatment and requires internet access for remote contacts and data collection.

Why it matters

Potential benefit: If successful, this approach could offer a simple, scalable way to help survivors lose weight and reduce long-term cardiometabolic risk.

How similar studies have gone: Time-restricted eating has produced modest weight and metabolic improvements in other adult studies, but combining TRE with structured coaching specifically in childhood cancer survivors is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Enrolled in the Childhood Cancer Survivor Study (a cohort of 5+ year survivors of childhood cancer diagnosed at age \< 21 between 1970-1999 at 31 participating institutions in North America)
* Are ≥18 years old
* Self-reported body mass index ≥ 25 kg/m2
* Are not pregnant or do not intend to become pregnant in the next year
* Stable weight over the past 3 months (+/- 10 pounds)
* If on oral medication for insulin resistance (ie, metformin), elevated blood pressure, or dyslipidemia, medication dose must be stable (ie, unchanged \> 3 months)
* Have internet access (can be via smartphone or computer). If neither device is available, the study can loan participants a Wi-Fi enabled device.

Exclusion Criteria:

* Do not reside in the United States
* Do not speak English
* Eating window \< 12 hours per 24-hour day
* On insulin or GLP-1 agonist
* Diagnosis of type 1 diabetes mellitus
* Enrolled in a formal weight management program or other weight loss trial
* History of an eating disorder

Where it's running

  • Memorial Sloan Kettering Cancer Center
    New York, New York, United States     Recruiting
  • St. Jude Children's Research Hospital (Data Collection Only)
    Memphis, Tennessee, United States     Recruiting
  • Hunter College
    New York, New York, United States     Not yet recruiting
  • Fred Hutchinson Cancer Research Center (Data Collection Only)
    Seattle, Washington, United States     Not yet recruiting

Study contacts

  • Principal investigator: Danielle Friedman, MD — Memorial Sloan Kettering Cancer Center
  • Study coordinator: Danielle Friedman, MD
  • Email: friedmad@mskcc.org
  • Phone: 1-833-MSK-KIDS

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.