Time-restricted eating for adult survivors of childhood cancer
Decreasing Cardiometabolic Risk in Childhood Cancer Survivors: The STRENGTH (Survivors Engaged in Time-Restricted EatiNG After THerapy) Study
This study will test whether time-restricted eating combined with regular coaching helps adult survivors of childhood cancer lose weight and lower heart and metabolic risk compared with standard education and monthly weigh-ins.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Memorial Sloan Kettering Cancer Center Academic / other |
| Locations | 4 sites (New York, New York and 3 other locations) |
| Trial ID | NCT07009288 on ClinicalTrials.gov |
What this trial studies
Adult survivors enrolled in the Childhood Cancer Survivor Study who meet weight criteria will be assigned to either a program of time-restricted eating plus motivational sessions with regular calls from a trained health coach or to usual care consisting of educational materials and monthly weight measurements. The intervention uses scheduled daily eating windows (TRE) alongside behavioral coaching and remote contacts to support adherence. Outcomes include weight change and cardiometabolic risk measures collected through monthly weights and participant questionnaires. The study does not provide cancer treatment and requires internet access for remote contacts and data collection.
Who should consider this trial
Good fit: Ideal candidates are adults (age ≥18) who are enrolled in the Childhood Cancer Survivor Study, have a BMI ≥25 kg/m2, are not pregnant, have stable medications and weight, and can access the internet (study can loan a device if needed).
Not a fit: People who live outside the United States, do not speak English, already keep an eating window under 12 hours, use insulin or GLP-1 agonists, have type 1 diabetes, or are enrolled in another formal weight-loss program are unlikely to benefit from or be eligible for this protocol.
Why it matters
Potential benefit: If successful, this approach could offer a simple, scalable way to help survivors lose weight and reduce long-term cardiometabolic risk.
How similar studies have performed: Time-restricted eating has produced modest weight and metabolic improvements in other adult studies, but combining TRE with structured coaching specifically in childhood cancer survivors is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Enrolled in the Childhood Cancer Survivor Study (a cohort of 5+ year survivors of childhood cancer diagnosed at age \< 21 between 1970-1999 at 31 participating institutions in North America) * Are ≥18 years old * Self-reported body mass index ≥ 25 kg/m2 * Are not pregnant or do not intend to become pregnant in the next year * Stable weight over the past 3 months (+/- 10 pounds) * If on oral medication for insulin resistance (ie, metformin), elevated blood pressure, or dyslipidemia, medication dose must be stable (ie, unchanged \> 3 months) * Have internet access (can be via smartphone or computer). If neither device is available, the study can loan participants a Wi-Fi enabled device. Exclusion Criteria: * Do not reside in the United States * Do not speak English * Eating window \< 12 hours per 24-hour day * On insulin or GLP-1 agonist * Diagnosis of type 1 diabetes mellitus * Enrolled in a formal weight management program or other weight loss trial * History of an eating disorder
Where this trial is running
New York, New York and 3 other locations
- Hunter College — New York, New York, United States (Not_yet_recruiting)
- Memorial Sloan Kettering Cancer Center — New York, New York, United States (Recruiting)
- St. Jude Children's Research Hospital (Data Collection Only) — Memphis, Tennessee, United States (Recruiting)
- Fred Hutchinson Cancer Research Center (Data Collection Only) — Seattle, Washington, United States (Not_yet_recruiting)
Study contacts
- Principal investigator: Danielle Friedman, MD — Memorial Sloan Kettering Cancer Center
- Study coordinator: Danielle Friedman, MD
- Email: friedmad@mskcc.org
- Phone: 1-833-MSK-KIDS
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.