Think Tank nutritional drink to help thinking after stress in middle-aged women.
A Double-blind, Placebo-controlled, Randomised, Acute, Repeated Measures Cross-over Study to Evaluate the Impact of Skoshify 'Think Tank' Nutritional Formulation on Cognitive Performance Following Stress Exposure.
This trial will test whether taking the 'Think Tank' nutritional drink helps thinking and mood after a physical and psychological stressor in healthy women aged 40–60 who drink caffeine daily.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 40 Years to 60 Years |
| Sex | Female |
| Sponsor | Leeds Beckett University Academic / other |
| Locations | 1 site (Leeds, West Yorkshire) |
| Trial ID | NCT07319117 on ClinicalTrials.gov |
What this trial studies
This randomized, double-blind, placebo-controlled, repeated-measures cross-over study compares an acute dose of the 'Think Tank' formulation plus caffeine versus placebo plus caffeine in healthy women aged 40–60. Participants complete two laboratory visits during which they undergo a standardized physical and psychological stress challenge while cognitive tests measure working memory, sustained attention, cognitive flexibility and inhibitory control. Physiological (heart rate, blood pressure, cortisol) and subjective (well-being, anxiety, mood, stress, fatigue, sleep quality, productivity) outcomes are recorded before and after the stressor. An initial health screening confirms eligibility and all testing is conducted in person at the university site.
Who should consider this trial
Good fit: Ideal candidates are healthy, non-smoking women aged 40–60 who drink caffeine daily and have no major physical or psychiatric conditions.
Not a fit: People with cardiovascular disease, current psychiatric diagnoses, regular recreational drug use, recent arm/hand injuries, smokers, or those taking prescription medications other than contraceptives or hormone replacement therapy are unlikely to qualify and may not benefit.
Why it matters
Potential benefit: If effective, the formulation could reduce stress-related declines in attention, memory and executive function and improve short-term well-being after stress.
How similar studies have performed: Individual ingredients such as creatine, magnesium, L-tyrosine, L-theanine, rhodiola, phosphatidylserine and citicoline have shown cognitive benefits under stress in prior studies, but the combined formulation's effects are largely untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Willing and able to provide written informed consent (in English) 2. Aged 40-60 3. Female 4. Daily caffeine drinkers 5. Healthy and free from significant physical and psychiatric disorders Exclusion Criteria: 1. Current cigarette smokers/vapers. 2. Known food allergy or intolerance to the investigational products or control products. 3. Not willing to consume coffee. 4. Individuals diagnosed with psychiatric/mental health conditions. 5. Individuals engaging in recreational drug use. 6. Individuals with diagnosed cardiovascular conditions (e.g. heart disease, high blood pressure) 7. Individuals taking prescribed medication except contraceptives/hormone replacement therapy 8. Individuals suffering from Raynaud's or circulatory issues 9. Individuals who have suffered an injury or infection in their hand/arm in the last month 10. Individuals who have suffered from chronic pain conditions or experience extreme numbness or pain in response to cold temperatures. 11. Previous brain injury/brain surgery 12. Individuals who work night shifts. 13. Currently pregnant or breastfeeding. 14. Previous participants in a laboratory stress protocol.
Where this trial is running
Leeds, West Yorkshire
- Leeds Beckett University — Leeds, West Yorkshire, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Zoe K Kolokotroni, PhD — Leeds Beckett University
- Study coordinator: Zoe K Kolokotroni, PhD
- Email: z.kolokotroni@leedsbeckett.ac.uk
- Phone: +441138123271
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.