Think Tank nutritional drink to help thinking after stress in middle-aged women.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind, placebo-controlled, repeated-measures cross-over study compares an acute dose of the 'Think Tank' formulation plus caffeine versus placebo plus caffeine in healthy women aged 40–60. Participants complete two laboratory visits during which they undergo a standardized physical and psychological stress challenge while cognitive tests measure working memory, sustained attention, cognitive flexibility and inhibitory control. Physiological (heart rate, blood pressure, cortisol) and subjective (well-being, anxiety, mood, stress, fatigue, sleep quality, productivity) outcomes are recorded before and after the stressor. An initial health screening confirms eligibility and all testing is conducted in person at the university site.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Willing and able to provide written informed consent (in English)
2. Aged 40-60
3. Female
4. Daily caffeine drinkers
5. Healthy and free from significant physical and psychiatric disorders

Exclusion Criteria:

1. Current cigarette smokers/vapers.
2. Known food allergy or intolerance to the investigational products or control products.
3. Not willing to consume coffee.
4. Individuals diagnosed with psychiatric/mental health conditions.
5. Individuals engaging in recreational drug use.
6. Individuals with diagnosed cardiovascular conditions (e.g. heart disease, high blood pressure)
7. Individuals taking prescribed medication except contraceptives/hormone replacement therapy
8. Individuals suffering from Raynaud's or circulatory issues
9. Individuals who have suffered an injury or infection in their hand/arm in the last month
10. Individuals who have suffered from chronic pain conditions or experience extreme numbness or pain in response to cold temperatures.
11. Previous brain injury/brain surgery
12. Individuals who work night shifts.
13. Currently pregnant or breastfeeding.
14. Previous participants in a laboratory stress protocol.

Where it's running

• Leeds Beckett University
  Leeds, West Yorkshire, United Kingdom Recruiting

Study contacts

• Principal investigator: Zoe K Kolokotroni, PhD — Leeds Beckett University
• Study coordinator: Zoe K Kolokotroni, PhD
• Email: z.kolokotroni@leedsbeckett.ac.uk
• Phone: +441138123271

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.