Theta stimulation to enhance cognitive function in Parkinson's disease
Theta Deep Brain Stimulation for Cognitive Enhancement in Parkinson's Disease
NA · University of British Columbia · NCT06518824
This study is testing if a special type of brain stimulation can help improve thinking skills in people with Parkinson's disease.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 27 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University of British Columbia (other) |
| Locations | 1 site (Vancouver, British Columbia) |
| Trial ID | NCT06518824 on ClinicalTrials.gov |
What this trial studies
This research aims to evaluate the effects of theta deep brain stimulation (DBS) on cognitive processing in patients with Parkinson's disease (PD). By targeting the associative circuitry of the subthalamic nucleus (STN), the study will compare cognitive task performance during theta stimulation versus a control condition. The study will recruit 27 subjects from the Vancouver General Hospital DBS clinic, utilizing a double-blind, randomized, cross-over design to ensure unbiased results. Participants will be monitored for their ability to complete cognitive tasks while receiving different stimulation conditions.
Who should consider this trial
Good fit: Ideal candidates are patients with Parkinson's disease who have deep brain stimulation systems and are at least three months post-operative.
Not a fit: Patients who are unable to complete cognitive tasks due to language barriers or advanced dementia may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve cognitive function and quality of life for patients with Parkinson's disease.
How similar studies have performed: While the approach of using theta stimulation in this context is novel, previous studies have shown promise in using DBS for cognitive enhancement in other conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Those with STN DBS devices * Those with pre- and post-operative imaging * Those that are at least 3 months post-operative Exclusion Criteria: * Those unable to complete the cognitive task (due to language barriers or dementia) * Those with significant DBS complications
Where this trial is running
Vancouver, British Columbia
- Leslie and Gordan Diamond Health Care Centre — Vancouver, British Columbia, Canada (RECRUITING)
Study contacts
- Study coordinator: Stefan Lang, MD PhD FRCSC
- Email: stefan.lang@vch.ca
- Phone: 604-875-5540
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Parkinson Disease, Cognitive Impairment, Theta Stimulation