Theta stimulation to enhance cognitive function in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to evaluate the effects of theta deep brain stimulation (DBS) on cognitive processing in patients with Parkinson's disease (PD). By targeting the associative circuitry of the subthalamic nucleus (STN), the study will compare cognitive task performance during theta stimulation versus a control condition. The study will recruit 27 subjects from the Vancouver General Hospital DBS clinic, utilizing a double-blind, randomized, cross-over design to ensure unbiased results. Participants will be monitored for their ability to complete cognitive tasks while receiving different stimulation conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Those with STN DBS devices
* Those with pre- and post-operative imaging
* Those that are at least 3 months post-operative

Exclusion Criteria:

* Those unable to complete the cognitive task (due to language barriers or dementia)
* Those with significant DBS complications

Where it's running

• Leslie and Gordan Diamond Health Care Centre
  Vancouver, British Columbia, Canada Recruiting

Study contacts

• Study coordinator: Stefan Lang, MD PhD FRCSC
• Email: stefan.lang@vch.ca
• Phone: 604-875-5540

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.