Theta-burst rTMS to improve self-reported motor symptoms in functional neurological disorder
Impact of Theta Burst Repetitive Transcranial Magnetic Stimulation on the Patient's Self-reported Improvement in Their Motor Functional Neurological Disorder
Hospital Center Guillaume Régnier · NCT07527403
This project will try neuronavigated theta-burst repetitive transcranial magnetic stimulation (rTMS) to see if adults with motor functional neurological disorder feel their symptoms have improved.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 22 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospital Center Guillaume Régnier (other) |
| Locations | 1 site (Rennes) |
| Trial ID | NCT07527403 on ClinicalTrials.gov |
What this trial studies
This is an observational study using neuronavigated theta-burst rTMS targeted based on current neuroimaging models of motor FND, with a focus on the right temporo-parietal junction. The main outcome is the patient's own report of overall change in motor symptoms, with additional clinician-rated measures, quality-of-life scales, and assessments of mood and dissociation. Treatments are noninvasive magnetic stimulation sessions applied repeatedly to a specific brain region. The protocol follows recent recommendations for clinical evaluation in FND research and compares patient and clinician perspectives on symptom change.
Who should consider this trial
Good fit: Adults (18+) diagnosed with motor FND by a neurologist who are eligible for and agree to neuronavigated rTMS and can provide consent.
Not a fit: People under legal protection, those deprived of liberty, individuals with non-motor FND only, or those unable to undergo rTMS are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this approach could noninvasively reduce motor symptoms and improve daily functioning and quality of life for people with motor FND.
How similar studies have performed: Several smaller studies and case series have reported positive signals for rTMS in FND, but results have been mixed and targets and outcome measures have varied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 18 * Patients with FND, either deficits or abnormal movements, diagnosed by a neurologist. * Patients with an indication for validated neuronavigated rTMS treatment. * Patients who have indicated that they do not object to participating in the study. Exclusion Criteria: * Patients subject to legal protection (legal guardianship, conservatorship, trusteeship) * Patients deprived of liberty
Where this trial is running
Rennes
- Centre Hospitalier Guillaume Régnier — Rennes, France (RECRUITING)
Study contacts
- Study coordinator: Dominique DRAPIER, PHD
- Email: d.drapier@ch-guillaumeregnier.fr
- Phone: +332 99 33 39 37
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Functional Neurological Disorder, Motor FND, Repetitive Transcranial Magnectic Stimulation, Theta burst rTMS