Theta-burst rTMS to improve self-reported motor symptoms in functional neurological disorder
Official title: Impact of Theta Burst Repetitive Transcranial Magnetic Stimulation on the Patient's Self-reported Improvement in Their Motor Functional Neurological Disorder
Run by Hospital Center Guillaume Régnier · NCT07527403 · Data updated 2026-11-12
This project will try neuronavigated theta-burst repetitive transcranial magnetic stimulation (rTMS) to see if adults with motor functional neurological disorder feel their symptoms have improved.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 22 (estimated) |
| Sponsor | Hospital Center Guillaume Régnier Academic / other |
| Locations | 1 site (Rennes) |
| Status | Recruiting |
| Started | March 13, 2026 |
| Main results expected | March 2028 |
| Study ends | March 2028 |
| Registry record updated | April 20, 2026 |
| Trial ID | NCT07527403 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) diagnosed with motor FND by a neurologist who are eligible for and agree to neuronavigated rTMS and can provide consent.
✕Probably not a fit
People under legal protection, those deprived of liberty, individuals with non-motor FND only, or those unable to undergo rTMS are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study using neuronavigated theta-burst rTMS targeted based on current neuroimaging models of motor FND, with a focus on the right temporo-parietal junction. The main outcome is the patient's own report of overall change in motor symptoms, with additional clinician-rated measures, quality-of-life scales, and assessments of mood and dissociation. Treatments are noninvasive magnetic stimulation sessions applied repeatedly to a specific brain region. The protocol follows recent recommendations for clinical evaluation in FND research and compares patient and clinician perspectives on symptom change.
Why it matters
Potential benefit: If successful, this approach could noninvasively reduce motor symptoms and improve daily functioning and quality of life for people with motor FND.
How similar studies have gone: Several smaller studies and case series have reported positive signals for rTMS in FND, but results have been mixed and targets and outcome measures have varied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 18 * Patients with FND, either deficits or abnormal movements, diagnosed by a neurologist. * Patients with an indication for validated neuronavigated rTMS treatment. * Patients who have indicated that they do not object to participating in the study. Exclusion Criteria: * Patients subject to legal protection (legal guardianship, conservatorship, trusteeship) * Patients deprived of liberty
Where it's running
-
Centre Hospitalier Guillaume Régnier
Rennes, France Recruiting
Study contacts
- Study coordinator: Dominique DRAPIER, PHD
- Email: d.drapier@ch-guillaumeregnier.fr
- Phone: +332 99 33 39 37
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.