Thermal ablation plus antithyroid medication for primary hyperthyroidism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows patients with primary hyperthyroidism who receive thermal ablation in combination with antithyroid drug therapy to document safety, symptom control, and cure rates. Participants are treated at a single center and monitored with clinical exams, thyroid hormone tests, and imaging over a defined follow-up period to record complications and recurrence. The study includes patients who have poor response or adverse reactions to standard drug therapy, are unsuitable for radioactive iodine, or decline surgery, and it documents procedural details and outcomes for real-world effectiveness data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients diagnosed with primary hyperthyroidism based on clinical manifestations and laboratory findings;
* Patients whose basal metabolic rate (BMR) remains within ±20% of the normal reference range, and whose resting heart rate is controlled at ≤90 beats/min;
* Patients with inadequate response to standard antithyroid drug (ATD) therapy, those experiencing severe adverse reactions to ATDs, those unsuitable for or unresponsive to radioactive iodine (RAI) therapy, or those who decline conventional surgical resection and wish to undergo ablation combined with medication to shorten the treatment course and achieve rapid improvement of hyperthyroid symptoms, including patients with mild, moderate, or severe disease;
* Patients with concomitant moderate-to-severe Graves' ophthalmopathy (GO);
* Patients with a safe needle trajectory for ablation access;
* Patients who are able to understand the purpose of the study, voluntarily participate, and provide written informed consent.

Exclusion Criteria:

* Severe coagulopathy;
* Poor general condition, such as concomitant severe cardiac, hepatic, renal, or other major organ dysfunction;
* Substernal goiter or a thyroid gland largely located in the retrosternal space (relative contraindication; staged treatment may be considered);
* Patients with malignant exophthalmos in whom the condition may worsen post-procedure;
* Patients with significant tracheal compression requiring urgent decompression;
* Unilateral vocal cord dysfunction confirmed by laryngoscopy;
* Women in the first or third trimester of pregnancy, lactating women, or those planning pregnancy in the near future.

Where it's running

• Chinese PLA General Hospital
  Beijing, China Recruiting

Study contacts

• Study coordinator: Zeyu Yang, Postgraduate
• Email: 987994761@qq.com
• Phone: 8618518118526

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Stent-assisted Coil Embolization for Acute Ruptured Intracranial Aneurysms

  This study tests whether stent-assisted coil embolization for ruptured intracranial aneurysms can be safely used in the acute period and help prevent rebleeding.

  Recruiting Tang-Du Hospital · Xi'an, Shaanxi · NCT07683377

• Biologic treatment for adults with ABPA and severe asthma

  This project will test whether biologic medicines help adults with ABPA who have severe asthma and elevated eosinophils.

  Recruiting Qianfoshan Hospital · Jinan, Shandong · NCT07362693

• Comparing a finger splint, paraffin baths, and peloidotherapy for trigger finger

  This tests whether a finger splint, paraffin baths, or peloidotherapy works best to reduce pain and catching in adults 18–75 with a single trigger finger.

  Recruiting Konya Beyhekim Training and Research Hospital · Konya, Konya · NCT07256522

• AI tool to detect thyrotoxic state using wearables in Graves’ disease

  A wearable-based AI tool is tested to see if it can flag thyrotoxicosis in adults with Graves’ disease by comparing heart-rate data during sleep to thyroid tests.

  Recruiting Thyroscope INC. · San Francisco, California · NCT07017907

• Comparing two types of radiation therapy for breast cancer

  This study is testing whether a new type of radiation therapy for breast cancer is safer and more effective than the standard treatment to help patients feel better and live longer.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06826885

• Evaluating diagnostic and therapeutic strategies for thyroid conditions

  This study is testing different ways to diagnose and treat thyroid problems, like hypothyroidism and thyroid cancer, to see which methods work best for patients.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06779747

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.