Therapist-guided online CBT for adults with chronic physical health conditions

Therapist-Guided Internet-Delivered Cognitive Behaviour Therapy (CBT) for Chronic Conditions (Chronic Conditions Course; CCC): Single-Group Predictors of Change in Routine Care

Not applicable Interventional University of Regina · NCT07233980

This project tests whether a therapist-guided online cognitive behavioral therapy course helps adults in Saskatchewan with chronic physical health conditions who have anxiety or depression.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment260 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Regina Academic / other
Locations2 sites (Regina, Saskatchewan and 1 other locations)
Trial IDNCT07233980 on ClinicalTrials.gov

What this trial studies

The program delivers a transdiagnostic internet-delivered cognitive behavioral therapy course (the Chronic Conditions Course, CCC) with therapist guidance through the Online Therapy Unit. Adults with diverse chronic physical health conditions complete the online modules while registered therapists provide personalized support to enhance adherence and treatment relevance. The study also analyzes which factors predict improvement, focusing on baseline symptom severity, adherence, treatment credibility, and therapeutic alliance. Outcomes include changes in depression, anxiety, disability, and other patient-reported measures collected during routine care and follow-up.

Who should consider this trial

Good fit: Adults aged 18 or older who live in Saskatchewan, have a self-reported diagnosed chronic physical health condition affecting their mental health, have internet access, and consent to treatment/research are eligible.

Not a fit: People with current severe psychiatric or medical conditions that need immediate treatment (e.g., active psychosis, mania, imminent suicide risk, urgent surgery), significant cognitive difficulties, or those living outside Saskatchewan are unlikely to benefit from or be eligible for this program.

Why it matters

Potential benefit: If successful, the CCC could reduce anxiety, depression, and disability for people with chronic conditions while using substantially less clinician time and improving access to care.

How similar studies have performed: Previous large randomized trials of the CCC by Dear and colleagues have shown significant and durable reductions in depression, anxiety, and disability, with effects comparable to face-to-face care.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Saskatchewan resident (as funding is provided by Saskatchewan government);
* Aged 18 years or older;
* self-reported diagnosed with chronic physical health condition affecting mental health;
* Access to a computer and the Internet;
* Consent to treatment/research

Exclusion Criteria:

* Current severe psychiatric or medical condition that requires immediate treatment and or would interfere with participation (e.g. current mania or psychosis, actively suicidal or unable to keep themselves safe, medical condition requiring immediate surgery or other invasive treatment, cognitive difficulties);
* Taking part in another treatment in our clinic;
* Living outside of Saskatchewan

Where this trial is running

Regina, Saskatchewan and 1 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Chronic Physical Health ConditionsInternet-delivered cognitive behavior therapyAnxietyDepressionChronic physical health conditionsTherapist assistancePredictors
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.