Testing the safety of AG-181 in healthy volunteers

A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability, and Pharmacokinetics of AG-181 in Healthy Participants

This study is testing the safety of a new drug called AG-181 by giving it to healthy volunteers in different doses to see how well they tolerate it.

Quick facts

• Phase: Phase 1
• Study type: Interventional
• Enrollment: 112 (estimated)
• Ages: 18 Years to 55 Years
• Sex: All
• Sponsor: Agios Pharmaceuticals, Inc. (Industry-sponsored)
• Locations: 1 site (Salt Lake City, Utah)
• Trial ID: NCT06286033 on ClinicalTrials.gov

What this trial studies

This study evaluates the safety and tolerability of AG-181 through a series of oral doses administered to healthy participants. It consists of three parts: a single ascending dose (SAD) phase, a multiple ascending dose (MAD) phase, and an assessment of how food affects the drug's pharmacokinetics. Participants will undergo thorough health screenings to ensure they meet the eligibility criteria, including specific body mass index and health status requirements. The study aims to gather important data on the drug's effects in a controlled environment.

Who should consider this trial

Good fit: Ideal candidates for this study are healthy adults aged 18 to 30 with a body mass index between 18.0 and 30.0 kg/m².

Not a fit: Patients with active or chronic diseases or those outside the specified health criteria may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into the safety profile of AG-181, paving the way for its use in future treatments.

How similar studies have performed: While this study focuses on a specific drug, similar studies assessing safety and tolerability in healthy volunteers have shown success in the past.

Eligibility criteria

Inclusion Criteria:

* Willing to participate in the study, give written informed consent, and comply with the study restrictions.
* Body mass index in the range of 18.0 to 30.0 kilograms per square meter (kg/m\^2).
* Weight ≥ 50 kilograms (kg) at screening.
* Healthy status as defined by the absence of evidence of any clinically significant, in the opinion of the Investigator, active or chronic disease following a detailed medical and surgical history, a complete physical examination including vital signs, 12-lead electrocardiogram (ECG), hematology, blood chemistry, serology, and urinalysis.
* Ability and willingness to refrain from alcohol-, caffeine-, and methylxanthine-containing beverages or food (e.g., coffee, tea, cola, chocolate, energy drinks) from 72 hours (3 days) before administration of the first dose of study drug through follow-up.
* All values for hematology and clinical chemistry tests of blood and urine within the normal range or showing no clinically relevant deviations, as judged by the Investigator.
* For women of child bearing potential (WOCBP)\*, have a negative serum pregnancy test at Screening and during admission to the clinic.

  a. \*WOCBP are defined as sexually mature women who have not undergone a hysterectomy, bilateral oophorectomy, or tubal occlusion; or who have not been naturally postmenopausal. WOCBP must use an acceptable method of contraception from Screening and until 14 days or 5 half-lives of AG-181, whichever is longer, after last dose of AG-181. WOCBP using hormonal contraception as a highly effective form of contraception must also use an acceptable barrier method.
* Male participants with female partners of childbearing potential must use a condom during treatment and for 14 days or 5 half-lives of AG-181, whichever is longer, after last dose of AG-181.
* Male participants must agree not to donate sperm during the study and for 14 days or 5 half-lives of AG-181, whichever is longer, after the last dose of study drug.
* Postmenopausal women are women who have not menstruated at all for at least the 12 months before providing informed consent and who have an elevated follicle-stimulating hormone (FSH) level indicative of menopause during screening.
* Participants must have discontinued use of prescription drugs (including topical skin preparations other than nonsteroidal/nonantibiotic nonprescription moisturizers) within 2 weeks or 5 half-lives (whichever is longer) of the first dose of study drug, and over-the-counter (OTC) medication (excluding routine vitamins) within 7 days of the first dose of study drug, unless agreed as not clinically relevant by the Investigator and Medical Monitor (or designee).

Exclusion Criteria:

* Women who are pregnant, lactating, or planning to attempt to become pregnant during this study or within 14 days or 5 half-lives of AG-181, whichever is longer, after last dose of study drug.
* Males with female partners who are pregnant, lactating, or planning to attempt to become pregnant during this study or within 14 days or 5 half-lives of AG-181, whichever is longer, after last dose of study drug.
* Prior exposure to AG-181.
* Use of any investigational drug or device within 30 days before administration of the first dose of study drug.
* Any disease which, in the opinion of the Investigator, poses an unacceptable risk to the participants.
* Clinically significant history of, including treatment within an Emergency Department for, any drug sensitivity, drug allergy, or food allergy, as determined by the Investigator (such as anaphylaxis, hepatotoxicity, or treatment with steroids or epinephrine).
* Creatinine clearance \<90 milliliters per minute (mL/min) (by Cockcroft-Gault formula) at screening.
* Aspartate aminotransferase \>upper limit of normal (ULN) or alanine aminotransferase \>ULN at screening.
* Use of tobacco or nicotine products in the 48 hours (2 days) prior to administration of the first dose of study drug.
* Strenuous activity, sunbathing, and contact sports within 48 hours (2 days) prior to administration of the first dose of study drug.
* History of donation of more than 450 milliliters (mL) of blood within 60 days prior to administration of the first dose of study drug.
* Plasma or platelet donation within 7 days prior to administration of the first dose of study drug.
* History within the 12 months before Screening of alcohol consumption exceeding 2 standard drinks per day on average (1 standard drink=12 ounce (oz) beer, 5 oz wine, and 1.5 oz spirits). Alcohol consumption will be prohibited 72 hours prior to administration of the first dose of study drug and until discharge.
* Positive test result for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibodies, or anti-human immunodeficiency virus (HIV) 1 and 2 antibodies at screening.
* Consumption of any nutrients known to modulate cytochrome P450 (CYP450) enzymes activity (e.g., grapefruit or grapefruit juice, pomelo juice, star fruit, or Seville \[blood\] orange products) within 14 days prior to administration of the first dose of study drug.
* Positive alcohol or drug screen (cannabinoids, amphetamines, methamphetamines, 3,4-methylenedioxy-N-methylamphetamine \[ecstasy\], opiates, methadone, oxycodone, phencyclidine, cocaine, cotinine, benzodiazepines, and barbiturates) at screening or admission to the clinical facility.
* Prolonged heart rate-corrected QT interval (QTc) \[heart rate-corrected QT interval by Fridericia's formula (QTcF) \>450 milliseconds (msec)\] during screening and prior to first dose of study drug.
* History of long-QT syndrome, torsade de pointes, or any risk factors for torsades de pointes in the opinion of the investigator.
* A history in any family member of any of the following: sudden cardiac death, unexplained death, long-QT syndrome, or death from a primary dysrhythmia potentially associated with QT prolongation.

Where this trial is running

Salt Lake City, Utah

• ICON 1255 East 3900 South — Salt Lake City, Utah, United States (Recruiting)

Study contacts

• Study coordinator: Agios Medical Affairs

Conditions Healthy Volunteers