Testing the safety and effects of DO-2 in patients with advanced solid tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a first-in-human, open-label, Phase 1 dose escalation study evaluating the safety and pharmacokinetics of DO-2 in patients with advanced or refractory solid tumors that have MET aberrations. The study consists of two parts, with an initial single-patient enrollment per cohort followed by a three-patient enrollment once grade 2 toxicity is observed. Patients will receive DO-2 orally, and the study aims to determine the appropriate dosing and safety profile of the drug.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years or older
* histologically or cytologically confirmed locally advanced, unresectable or metastatic NSCLC, no longer eligible for approved, available standard therapies. To be entered patients must have proven MET exon 14 skipping mutation, determined by local next generation sequencing (NGS), whole exome sequencing (WES), whole transcriptome sequencing (WTS) or other genomic analysis methods, from an assessment not older than 3 months
* measurable disease in accordance with RECIST 1.1
* Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1
* adequate bone marrow function, without the support of cytokines
* adequate liver function
* adequate renal function with serum creatinine \<1 x institutional UNL and GFR within normal range
* agree to follow the contraception requirements of the trial
* signed informed consent, indicating study patients understand the purpose of and procedures required for the study and are willing to participate in the study.

Exclusion Criteria:

* tumour harbouring other known oncogenic mutations promoting tumour growth
* major surgery within 3 weeks before enrolment
* chemotherapy (in the case of nitrosoureas and mitomycin C within 6 weeks), radiotherapy, immunotherapy, or any other study drug within 3 weeks before study drug administration
* antibody based cancer therapy within 4 weeks before administration of the first dose of DO-2
* patients who became progressive on previous treatment with a MET-kinase inhibitor
* patients with brain metastases are excluded unless all of the following criteria are met:

  1. CNS lesions are asymptomatic and previously treated
  2. No ongoing requirement for corticosteroids as therapy for CNS metastases
  3. Imaging demonstrates stability of disease \> 28 days from last treatment for CNS metastases
* leptomeningeal involvement (leptomeningeal carcinomatosis)
* history of uncontrolled heart disease including unstable angina, congestive heart failure, myocardial infarction within preceding 12 months, clinically significant rhythm or conduction abnormality, congenital long QT syndrome, obligate use of a cardiac pacemaker, QTc at screening greater than 450 milliseconds in males and greater than 470 milliseconds in females
* uncontrolled arterial hypertension despite appropriate therapy
* positive pregnancy test (urinary beta-hCG) at screening (applicable to women of child-bearing potential who are sexually active)
* mental status alteration or history of major psychiatric illness, which may potentially impair patient's compliance with study procedures
* signs and symptoms of active infection requiring systemic therapy
* other medical condition (e.g. pre-existing kidney dysfunction) that in the opinion of the investigator makes it undesirable for a patient to participate
* inability or unwillingness to swallow capsules and malabsorption syndrome or other condition that would interfere with enteral absorption

Where it's running

• Institut Roi Albert II - UC Louvain
  Brussels, Belgium Recruiting
• Uza
  Edegem, Belgium Recruiting
• Universitair Ziekenhuis Gent
  Ghent, Belgium Recruiting
• UZ Leuven
  Leuven, Belgium Recruiting
• Institut Bergonie
  Bordeaux, France Recruiting
• Institut Cœur Poumon - CHU Lille
  Lille, France Recruiting

Study contacts

• Study coordinator: Timothy Perera, PhD
• Email: tperera@deuteroncology.com
• Phone: +32473558353

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.