Testing HRS-1167 for advanced solid tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the safety, tolerability, and anti-cancer activity of HRS-1167 as a standalone treatment for patients with advanced solid tumors. It includes a dose escalation phase and an efficacy expansion phase focusing on specific cancer types such as ovarian, breast, pancreatic, and prostate cancers with HRR gene mutations. Participants must have advanced malignancies that are resistant to standard therapies or for which no standard treatment exists. The study aims to gather data on the drug's effectiveness and side effects in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18；
2. ECOG performance status 0-1;
3. Life expectancy is not less than 12 weeks;
4. Dose escalation and PK expansion part: Subjects diagnosed with advanced solid malignancies who are refractory to standard therapies or for which no standard therapy exists；
5. Efficacy expansion part：Ovarian Cancer、Breast Cancer、Pancreatic Cancer、Prostate Cancer or other cancer types with HRR gene mutation；
6. At least one target lesion (except maintenance therapy);
7. Adequate organ and marrow function as defined by the protocol.

Exclusion Criteria:

1. Surgery or chemotherapy within 4 weeks of the first dose of study treatment；
2. Subjects that are unable to swallow, or dysfunction of gastrointestinal absorption；
3. Active HBV/HCV/HIV infection;
4. Untreated and/or uncontrolled brain metastases.

Where it's running

• Cancer Hospital Chinese Academy of Medical Sciences
  Beijing, Beijing Municipality, China Recruiting
• Chongqing Cancer Hospital
  Chongqing, Chongqing Municipality, China Recruiting
• Guangxi Medical University Affiliated Tumor Hosipital
  Nanning, Guangxi, China Recruiting
• Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
  Guangzhou, Guangzhou, China Recruiting
• Harbin Medical University Cancer Hospital
  Harbin, Heilongjiang, China Recruiting
• Henan Cancer Hospital
  Zhengzhou, Henan, China Recruiting

Study contacts

• Study coordinator: Quanren Wang, M.D
• Email: quanren.wang@hengrui.com
• Phone: +86 18036618570

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.