Testing how well people tolerate low oxygen during exercise
Graded Exercise Hypoxia Testing
This study is testing how well people can handle low oxygen levels during exercise to see what helps some individuals perform better than others.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 2 sites (Rochester, Minnesota and 1 other locations) |
| Trial ID | NCT06901284 on ClinicalTrials.gov |
What this trial studies
This observational study aims to create a standardized test to assess individual tolerance to acute hypoxia through graded exercise. It will evaluate various factors such as ventilatory compensation, heart rate response, and pulmonary function to understand why some individuals perform better in low oxygen conditions than others. The findings could guide future strategies to improve exercise performance in hypoxic environments, both pharmacologically and non-pharmacologically.
Who should consider this trial
Good fit: Ideal candidates are physically active individuals who engage in at least 150 minutes of moderate physical activity per week.
Not a fit: Patients with contraindications to exercise testing, significant musculoskeletal or metabolic diseases, or those with a body mass index outside the specified range may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for enhancing exercise tolerance in low oxygen conditions for various patient populations.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in understanding exercise tolerance in hypoxic conditions, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • Physically active (≥150 minutes of moderate physical activity per week) Exclusion Criteria: * Contraindications to exercise testing * Currently pregnant * Musculoskeletal or metabolic disease * Allergies to lidocaine * Body-mass index ≤18 or ≥35 kg·m-2 * Pacemaker * No confounding cardiorespiratory disease * Persistent tobacco use (\>15 pack years)
Where this trial is running
Rochester, Minnesota and 1 other locations
- Mayo Clinic — Rochester, Minnesota, United States (Recruiting)
- St. Mary's Hospital — Rochester, Minnesota, United States (Not_yet_recruiting)
Study contacts
- Principal investigator: Michael Joyner, M.D. — Mayo Clinic
- Study coordinator: Nancy Meyer
- Email: meyer.nancy2@mayo.edu
- Phone: 507-255-0913
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.