Testing HB-1 for treating Panic Disorder

Efficacy and Safety of HB-1 for Panic Disorder: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

This study is testing a new medication called HB-1 to see if it can help adults with Panic Disorder feel better compared to a placebo and two other treatments.

Quick facts

• Phase: PHASE2
• Study type: Interventional
• Enrollment: 240 (estimated)
• Ages: 18 Years to 65 Years
• Sex: All
• Sponsor: HB BioTech, LLC (industry)
• Locations: 22 sites (Canberra, Australian Capital Territory and 21 other locations)
• Trial ID: NCT06483789 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to evaluate the safety and efficacy of HB-1 compared to a placebo and two other medications in adults aged 18 to 65 with Panic Disorder. It is a multicenter, randomized, double-blind, placebo-controlled trial that will enroll approximately 240 to 600 participants. Patients will receive treatment for 12 weeks, followed by a safety follow-up visit one week after their last dose. Both patients and researchers will be blinded to the treatment assignments to ensure unbiased results.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 65 who meet the DSM-V criteria for Panic Disorder and have experienced at least one panic attack in the week prior to screening.

Not a fit: Patients who do not meet the diagnostic criteria for Panic Disorder or have unstable medical conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new effective option for patients suffering from Panic Disorder.

How similar studies have performed: Other studies have shown promise in treating Panic Disorder with similar pharmacological approaches, but the specific efficacy of HB-1 is yet to be established.

Eligibility criteria

Inclusion Criteria:

1. Male or female aged 18 to 65 years old, inclusive, at the time of informed consent.
2. Meets Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-V) Criteria for Panic Disorder.
3. Minimum of one full, unexpected panic attack in week prior to screening (via Diagnostic and Statistical Manual of Mental Disorders 5th edition \[DSM-V\] based structured interview).
4. Medically stable on current medication regimen for at least 3 months (including as needed \[PRN\] medications), as determined by Investigator.
5. Willing to remain on current doses of other psychiatric medications throughout the length of the trial.
6. Willing and able to safely stop / avoid any of the following prior to study trial: Inhibitors or inducers of CYP3A4 (grapefruit juice, erythromycin, ritonavir, telithromycin, rifampin), HMG-CoA Reductase Inhibitors (Simvastatin, Lovastatin, Atorvastatin), Beta Blockers (Timolol eyedrops, Metoprolol), Neuromuscular Blocking Agents (curare-like and depolarizing), Antihypertensive Agents (Prazosin and vasodilators, angiotensin-converting enzyme inhibitors, diuretics, beta blockers), Inhalation Anesthetics, Disopyramide, Flecainide, Quinidine, Cimetidine, Lithium, Carbamazepine, Phenobarbital, Cyclosporine, Digitalis, Aliskiren, Ramipril and Ramiprilat, aspirin, propranolol.
7. Willing and able to safely stop / avoid sensitive P-glycoprotein inhibitors.
8. Willing to take HB-1, telmisartan, verapamil, or placebo.
9. Willing and able to provide informed consent indicating an understanding of the requirements of the study and a willingness to comply with scheduled visits and all study procedures.
10. Female subjects must be surgically sterile (or have a monogamous partner who is surgically sterile) or be at least 2 years postmenopausal or commit to use 2 acceptable forms of birth control (defined as the use of an intrauterine device, a barrier method with spermicide, condoms, any form of hormonal contraceptives, or abstinence) for the duration of the study and for 4 months following the last dose of study treatment. Male subjects must be sterile (biologically or surgically) or commit to the use of a reliable method of birth control (condoms ± spermicide) for the duration of the study and for 4 months following the last dose of study treatment. Individuals who are involved exclusively in same-sex relationships are exempt from the birth control requirements but must agree to abide by the recommendations if they do engage in a heterosexual relationship.
11. Female subjects who are women of childbearing potential (WOCBP) must have a negative pregnancy test at Screening, within 7 days of dosing with study treatment.

Exclusion Criteria:

1. Any concomitant disease, condition, or treatment that could interfere with the conduct of the study, or that would, in the opinion of the Investigator or Sponsor, pose an unacceptable risk to the participant in the study or interfere with the interpretation of study data.
2. Concurrent treatment with benzodiazepines (e.g. alprazolam, diazepam, clonazepam, lorazepam) as assessed by clinical interview and urine toxicology testing.
3. Severe Agoraphobia (Panic Disorder Symptom Severity Scale (PDSS) Item 4 "agoraphobic fear/avoidance" \> 2).
4. Severe Generalized Anxiety (Hamilton Anxiety Rating Scale \[HAM-A\] Total Score \> 23).
5. Prior lifetime history of suicide attempt, Columbia Suicide Severity Rating Scale (C-SSRS) ≥ 4 in the past 6 months or prior lifetime history of hospitalization for depression.
6. Diagnosis of Substance Use Disorder, Obsessive-Compulsive Disorder (OCD), Bipolar I, Bipolar II disorder or schizoaffective or other psychotic disorders (per Structure Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-V) \[SCID-V\].
7. Severe uncontrolled cardiac disease within 6 months of Screening, including but not limited to uncontrolled hypertension, hypotension (defined as below 90/60); unstable angina; myocardial infarction (MI) or cerebrovascular accident (CVA).
8. Any clinically significant electrocardiogram (ECG) abnormalities at screening.
9. Inadequate hepatic function defined as total bilirubin \> 1.5 × the upper limit of normal (ULN) ranges of each institution, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \> 3 × the ULN range of each institution.
10. Inadequate renal function defined as serum creatinine \> 1.5 × the upper limit of normal (ULN) range of each institution and/or estimated glomerular filtration rate (eGFR) \< 60.
11. Any clinically significant abnormalities in clinical laboratory assessments as assessed by the Investigator.
12. Any other systemic conditions or organ abnormalities that in the opinion of the Investigator may interfere with the conduct and/or interpretation of the current study.
13. Unable to complete neuropsychological testing.
14. Already on treatment with either telmisartan or verapamil or both.
15. Has a history of hypersensitivity or severe allergic reaction to either telmisartan or verapamil, or any component of either licensed drug.
16. Documented contraindication to taking telmisartan or verapamil: (e.g., Duchenne's muscular dystrophy, myasthenia gravis).
17. Pregnant or breastfeeding.
18. Participation in another current clinical trial or prior trial within the last three months.
19. Urinalysis evidence of exposure to substances that may interfere with HB-1 testing (per investigator discretion).

Where this trial is running

Canberra, Australian Capital Territory and 21 other locations

• Paratus Clinical Research Canberra — Canberra, Australian Capital Territory, Australia (RECRUITING)
• Paratus Clinical Research Western Sydney — Blacktown, New South Wales, Australia (RECRUITING)
• East Sydney Doctors — Darlinghurst, New South Wales, Australia (RECRUITING)
• Momentum Clinical Research Darlinghurst — Darlinghurst, New South Wales, Australia (RECRUITING)
• Paratus Clinical Research Central Coast — Kanwal, New South Wales, Australia (RECRUITING)
• Novatrials — Kotara, New South Wales, Australia (RECRUITING)
• Canopy Clinical Sutherland — Miranda, New South Wales, Australia (RECRUITING)
• Innovate Clinical Research — Waitara, New South Wales, Australia (RECRUITING)
• Westmead Hospital — Westmead, New South Wales, Australia (RECRUITING)
• Canopy Clinical Wollongong — Wollongong, New South Wales, Australia (RECRUITING)
• Paratus Clinical Research Brisbane — Herston, Queensland, Australia (RECRUITING)
• Mackay Hospital and Health Service — Mackay, Queensland, Australia (RECRUITING)
• Gold Coast University Hospital — Southport, Queensland, Australia (RECRUITING)
• South Australian Health and Medical Research Institute — Adelaide, South Australia, Australia (RECRUITING)
• Lyell McEwin Hospital — Elizabeth Vale, South Australia, Australia (WITHDRAWN)
• Grampians Health — Ballarat, Victoria, Australia (WITHDRAWN)
• NeuroCentrix — Carlton, Victoria, Australia (RECRUITING)
• Peninsula Therapeutic and Research Group — Frankston, Victoria, Australia (COMPLETED)
• Multidisciplinary Alfred Psychiatry Research Clinic — Melbourne, Victoria, Australia (RECRUITING)
• Ramsay Clinic Albert Road — Melbourne, Victoria, Australia (RECRUITING)
• Paratus Clinical Research Melbourne — Northcote, Victoria, Australia (RECRUITING)
• Clinitrials — Perth, Western Australia, Australia (RECRUITING)

Study contacts

• Principal investigator: Prof. Malcolm Hopwood — Ramsay Clinic Albert Road
• Study coordinator: Karen Smith

Conditions: Panic Disorder, Mental Illness