Testing for Teicoplanin Allergy Using Patients' Own Blood
Official title: Improving The Sensitivity of Teicoplanin Allergy Testing By Using Autologous Serum
Run by University Hospital Southampton NHS Foundation Trust · NCT06803758 · Data updated 2026-11-12
This study is testing a new way to check if patients who had a serious allergic reaction to Teicoplanin are really allergic by using their own blood to make the allergy test more accurate.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University Hospital Southampton NHS Foundation Trust Academic / other |
| Locations | 1 site (Southampton) |
| Status | Recruiting |
| Started | January 8, 2025 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | January 31, 2025 |
| Trial ID | NCT06803758 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who have experienced suspected anaphylaxis during anesthesia involving Teicoplanin.
✕Probably not a fit
Patients who are pregnant, under 18 years old, or have certain medical conditions that interfere with testing will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to improve the reliability of allergy testing for Teicoplanin, a drug associated with serious allergic reactions. Patients who have experienced anaphylaxis during anesthesia and have received Teicoplanin will participate in the study. The approach involves mixing Teicoplanin with the patients' own blood to enhance the accuracy of skin testing. By doing so, the researchers hope to identify patients who are truly allergic to Teicoplanin, thereby preventing future life-threatening reactions.
Why it matters
Potential benefit: If successful, this study could lead to more accurate allergy testing for Teicoplanin, reducing the risk of serious allergic reactions in patients.
How similar studies have gone: While allergy testing for other drugs has been reliable, this approach to Teicoplanin allergy testing is novel and has not been extensively tested before.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients 18 years old and above who have suffered suspected anaphylaxis under anaesthesia (the 'index episode'), where teicoplanin has been given Exclusion Criteria: * Patients unable to stop drugs that would interfere with skin tests prior to study- e.g. antihistamines or certain anti-psychotics * Pregnancy * Patients under age 18 years * Patients with elevated baseline mast cell tryptase requiring further investigation * Patients with blood-borne viruses such as Hep B, C and HIV
Where it's running
-
University Hospital Southampton
Southampton, United Kingdom Recruiting
Study contacts
- Study coordinator: Linda Nel, MB BCh FRCA
- Email: linda.nel@uhs.nhs.uk
- Phone: 07957543839
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.