Testing for Coronary Spasm in Patients with Chest Pain
Abnormal Coronary Vasomotion in Patients With Suspected CAD But Normal Coronary Arteries
This study is testing if a special test can find out if chest pain in adults with normal heart scans is caused by temporary narrowing of the heart arteries.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1000 (estimated) |
| Ages | 35 Years and up |
| Sex | All |
| Sponsor | Robert Bosch Medical Center Academic / other |
| Locations | 1 site (Stuttgart) |
| Trial ID | NCT00921856 on ClinicalTrials.gov |
What this trial studies
This study investigates patients with suspected coronary artery disease (CAD) who have normal coronary angiograms. It utilizes an intracoronary acetylcholine provocation test to determine if coronary vasospasm is present, which could explain the patients' symptoms of chest pain or shortness of breath. By identifying coronary spasms, the study aims to provide insights into the underlying causes of these symptoms and guide appropriate treatment options. The study focuses on adults aged 35 to 95 with specific eligibility criteria related to their heart health.
Who should consider this trial
Good fit: Ideal candidates are adults aged 35 to 95 with angina pectoris or dyspnea suggestive of CAD and non-invasive evidence of coronary ischemia.
Not a fit: Patients under 35 or over 95 years old, or those with severe chronic obstructive pulmonary disease, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify the cause of chest pain in patients with normal coronary arteries, leading to more effective treatment options.
How similar studies have performed: Similar studies using acetylcholine testing have shown promise in identifying coronary vasospasm, suggesting this approach is supported by prior research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults between 35 and 95 years old with angina pectoris and/or dyspnea suggestive of coronary artery disease with non-invasive proof of coronary ischemia or high pre-test probability for CAD who will be referred for coronary angiography * Serum creatinine \< 1,4 md/dl * Left ventricular ejection fraction \> 50% Exclusion Criteria: * Patients under 35 years and above 95 years of age * Severe chronic obstructive pulmonary disease (contraindication for acetylcholine-testing)
Where this trial is running
Stuttgart
- Robert Bosch Medical Center — Stuttgart, Germany (Recruiting)
Study contacts
- Principal investigator: Peter Ong, MD — Robert Bosch Medical Center
- Study coordinator: Peter Ong, MD
- Email: petereong@gmail.com
- Phone: +4971181015449
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.