Testing early signs of dementia in patients with smell disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between idiopathic olfactory dysfunction and early warning signs of dementia with Lewy bodies (DLB). It utilizes a novel technique called Real-Time Quaking-Induced Conversion (RT-QuIC) to measure misfolded alpha-synuclein in patients with olfactory dysfunction compared to healthy controls. The study seeks to identify biomarkers and prodromal symptoms that could facilitate earlier diagnosis and intervention for DLB. By understanding these early signs, the research hopes to improve patient care and support the development of disease-modifying therapies.

Why it matters

Who can join: the full rules

Inclusion criteria with patients iOD:

* Age 55 -75 years of age
* Slowly progressing and non-fluctuating iOD
* Able to give informed consent and to cooperate as evaluated by the PI

Exclusion criteria with patients iOD:

* Diagnosed with a neurodegenerative disease or major neurological/psychiatric condition.
* Anosmia/hyposmia caused by sino-nasal disease (including chronic rhinitis and allergy), after trauma, infection, congenial, olfactory dysfunction due to surgery, or toxins/drugs affecting the olfactory function.
* Olfactory dysfunction with response to systemic or local corticosteroids if tried
* Severe nasal cavity abnormalities or infections.
* Overt signs of dementia or PD
* Current alcohol or drug abuse
* Terminal illness
* Diagnosed with neurodegenerative disease or major neurological/psychiatric condition.

Inclusion criteria controls:

* Age 55 -75 years of age
* Able to give informed consent
* Able to cooperate as evaluated by the PI

Exclusion criteria controls:

* Olfactory dysfunction on clinical test
* Overt signs of dementia or PD
* Severe nasal cavity abnormalities or infections.
* Current alcohol or drug abuse
* Diagnosed with neurodegenerative disease or major neurological/psychiatric condition.

Where it's running

• Danish Dementia Research Centre
  Copenhagen, Denmark Recruiting
• Oskar McWilliam
  Copenhagen, Denmark Recruiting

Study contacts

• Principal investigator: Kristian S Frederiksen — Danish Dementia Research Centre, Rigshospitalet, Capital Region
• Study coordinator: Oskar McWilliam
• Email: oskar.mcwilliam@regionh.dk
• Phone: +4535458759

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.