Testing CBP-1018 in patients with advanced solid tumors

An Open-Label, Non-randomized, Multi-center Phase I Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Bi-Ligand-Drug Conjugate CBP-1018 in Patients With Advanced Solid Tumors

This study is testing a new drug called CBP-1018 to see if it can help people with advanced solid tumors feel better and tolerate the treatment.

Quick facts

• Phase: Phase 1
• Study type: Interventional
• Enrollment: 170 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Coherent Biopharma (Suzhou) Co., Ltd. (Industry-sponsored)
• Drugs / interventions: chemotherapy, immunotherapy, radiation
• Locations: 2 sites (Guangzhou, Guangdong and 1 other locations)
• Trial ID: NCT04928612 on ClinicalTrials.gov

What this trial studies

This open-label, non-randomized, multi-center phase I study evaluates the bi-ligand-drug conjugate CBP-1018 in patients with advanced solid tumors. The study consists of two parts: Part A focuses on dose escalation to assess safety, tolerability, pharmacokinetics, and preliminary efficacy, while Part B involves dose expansion. Participants will receive CBP-1018 until disease progression or unacceptable toxicity occurs, with safety monitored by a committee throughout the trial.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older with pathologically documented advanced solid tumors who have received prior standard therapy.

Not a fit: Patients who have not received prior standard therapy or those with a life expectancy of less than three months may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a new treatment option for patients with advanced solid tumors.

How similar studies have performed: Other studies involving bi-ligand-drug conjugates have shown promise, suggesting potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

* Provision of informed consent (ICF) prior to any study-specific procedures.
* Men or women ≥ 18 years old when signed ICF.
* Eastern Cooperative Oncology Group (ECOG) performance status 0-1.
* Life expectancy of ≥ 3 months, in the opinion of the Investigator.
* Pathologically documented, advanced solid tumor including metastatic castration resistant prostate cancer (mCRPC), advanced renal cell cancer (RCC), advanced lung squamous cell cancer (LSCC), etc.
* Subjects must have received prior standard therapy appropriate for their tumor type and stage of disease, or in the opinion of the Investigator, would be unlikely to tolerate or derive clinically meaningful benefit from appropriate standard of care therapy.
* At least one non-irradiated measurable lesion per RECIST 1.1 or bone lesion per PCWG3 (only for mCRPC), optional for low dose level (≤ 0.08 mg/kg) of Part A.
* Available archived or fresh tumor tissue samples, optional for low dose level (≤ 0.08 mg/kg) of Part A.
* Adequate bone marrow and organ function, defined as:
* Absolute neutrophil count (ANC) ≥ 1.5 × 109/L, not requiring growth factor support for at least 28 days prior to the first dose of CBP-1018.
* Hemoglobin (Hb) ≥ 100 g/L, not requiring transfusion support for at least 14 days or growth factor support for at least 28 days prior to the first dose of CBP-1018.
* Platelet count ≥ 100 × 109/L, not requiring transfusion support for at least 7 days prior to the first dose of CBP-1018.
* Total bilirubin (TBIL) ≤ 1.5 × ULN, alkaline phosphatase (ALP) ≤ 1.5 × ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3.0× ULN if no demonstrable liver metastases.
* TBIL≤ 1.5 × ULN, ALT and AST ≤ 5.0 × ULN in the presence of liver metastases.
* TBIL \< 2.0 × ULN for subjects with documented Gilbert's syndrome or \< 3.0 × ULN for subjects for whom the indirect bilirubin level suggests an extrahepatic source of elevation.
* Creatinine ≤ 1.0 × ULN, or creatinine clearance ≥ 50 mL/min as calculated using Cockcroft-Gault formula.
* International Normalized Ratio (INR) ≤ 1.5 × ULN (within the therapeutic range for subjects receiving anticoagulation therapeutic) and activated partial thromboplastin time (APTT) ≤ 1.5 × ULN.
* LVEF ≥ 50% by either echocardiography (ECHO) or multiple-gated acquisition (MUGA).
* Female subjects of childbearing/reproductive potential must have a negative urine or serum pregnancy test within 72 hours prior to receiving the first dose of CBP-1018. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required.
* Male subjects of fathering potential and subjects of childbearing/reproductive potential must agree to use highly effective methods of contraception (see Appendix 4) throughout the study and for at least 30 days after the last dose of CBP-1018.

Exclusion Criteria:

* Known prior or suspected hypersensitivity to study drugs or any component in their formulations.
* Concurrent malignancy within 5 years prior to the first dose of CBP-1018, other than adequately treated cervical carcinoma-in-situ, localized squamous cell cancer of the skin, basal cell carcinoma, prostate cancer not requiring treatment, ductal carcinoma in situ of the breast, or \< T1 urothelial carcinoma.
* Active central nervous system (CNS) metastases. Previously diagnosed CNS metastases are eligible if have been treated and recovered from the acute effects of radiation therapy or surgery prior to the first dose of CBP-1018, have discontinued corticosteroid treatment for CNS metastases for at least 4 weeks and are neurologically stable.
* Major surgery, systemic anticancer therapy (chemotherapy, targeted therapy, immunotherapy, endocrine therapy, biotherapy) or participation in other therapeutic studies within 4 weeks prior to the first dose of CBP-1018.
* Radiotherapy administrated within 21 days prior to the first dose of CBP-1018, or localized palliative radiotherapy administered within 7 days prior to the first dose of CBP-1018.
* Any toxicities attributed to prior anti-cancer therapy, other than alopecia and fatigue, that have not resolved to Grade 1 (NCI CTCAE 5.0) or baseline prior to the first dose of CBP-1018.
* Poorly controlled concurrent diseases as diabetes, hypertension (systolic blood pressure \>160 mmHg or diastolic blood pressure \> 100 mmHg), etc.
* History of any of the following cardiovascular conditions within 12 months of enrollment: cardiac angioplasty or stenting, myocardial infarction, unstable angina, coronary artery by-pass graft surgery, symptomatic peripheral vascular disease, class III or IV congestive heart failure, as defined by the New York Heart Association.
* History of clinically significant lung diseases as interstitial pneumonia, pneumonitis, pulmonary fibrosis, and severe radiation pneumonitis, or suspected to have these diseases by imaging at screening period.
* Active bleeding disorder or other history of grade ≥ 3 hemorrhage within 4 weeks prior to the first dose of CBP-1018.
* Requirement of anticoagulant therapy with oral vitamin K antagonists. Low-dose anticoagulants for maintenance of patency of central venous access device or prevention of deep venous thrombosis is allowed. Therapeutic use of low molecular weight heparin is allowed.
* History of deep vein thrombosis or pulmonary embolism within 6 months prior to the first dose of CBP-1018.
* Active infection requiring intravenous (IV) antibiotics within 1 weeks prior to the first dose of CBP-1018.
* Known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS).
* Positive Hepatitis B Surface Antigen (HepBsAg) (indicative of chronic Hepatitis B), positive Hepatitis total core antibody with negative HepBsAg (suggestive of occult hepatitis B) or detectable Hepatitis C virus Ribonucleic acid (RNA) by PCR (Hepatitis C Antibody test for screening, followed by PCR for Hepatitis C virus RNA if HepCAb is positive).
* Live-virus vaccination within 30 days prior to the first dose of CBP-1018. Seasonal influenza vaccines that do not contain live virus are allowed.
* Current or anticipated need for treatment with strong cytochrome P450 3A4 (CYP3A4) inhibitors or inducers.
* History or current evidence of any other condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the Investigator.

Where this trial is running

Guangzhou, Guangdong and 1 other locations

• Sun Yat-Sen memorial hospital, Sun Yat-Sen University — Guangzhou, Guangdong, China (Not_yet_recruiting)
• Tianjin Medical University Cancer Institute and Hospital — Tianjin, Tianjin Municipality, China (Recruiting)

Study contacts

• Principal investigator: Hai Huang, Ph D — Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
• Study coordinator: Jiangang Yu, Ph D

Conditions Solid Tumor