Testing blood samples for esophageal cancer treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of liquid biopsies in monitoring minimal residual disease (MRD) in patients with resectable esophageal cancer. It involves both retrospective and prospective collection of blood samples at various stages of treatment, including before and after surgery, and during adjuvant therapies. Patients will be grouped based on their treatment scenarios, allowing for tailored analysis of circulating tumor DNA (ctDNA) throughout their treatment journey. The study seeks to enhance understanding of disease progression and treatment response through non-invasive testing.

Why it matters

Who can join: the full rules

Key inclusion criteria are:

1. Male or female, age \> 18 years
2. New diagnosis of esophageal cancer, pathologically confirmed squamous cell carcinoma (ESCC) or adenocarcinoma (EAC)
3. Clinically staged - cT1-4 N0-2 M0 (local or locally advanced, resectable)
4. Eligible for multidisciplinary treatment as assessed by MDT
5. Able to provide informed consent (ICF) according to Good Clinical Practice and national/European regulations

Key exclusion criteria are:

1. (Oligo)metastatic disease
2. Histologically or cytologically confirmed diagnosis other than squamous cell carcinoma or adenocarcinoma (eg. neuroendocrine carcinoma, lymphoma…)
3. Other active malignancies
4. Previous exposure to chemoradiation (prior to MDT)
5. Treatment plan after MDT: neoadjuvant chemotherapy with no radiation or chemoradiation with definitive intent (surgery is not planned)

Where it's running

• Uza
  Antwerp, Belgium Recruiting
• UZ Gent
  Ghent, Belgium Recruiting
• UZLeuven
  Leuven, Belgium Recruiting
• AZ Delta
  Roeselare, Belgium Recruiting

Study contacts

• Principal investigator: Jeroen Dekervel, MD — Universitaire Ziekenhuizen KU Leuven
• Study coordinator: Jeroen Dekervel, MD
• Email: jeroen.dekervel@uzleuven.be
• Phone: 016344225

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.