Testing antiarrhythmic drugs for atrial fibrillation based on genetics

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to enroll patients with frequent symptomatic episodes of atrial fibrillation (AF) to evaluate the effectiveness of two different classes of antiarrhythmic drugs (AADs), Flecainide and Sotalol. Participants will be assessed in a cross-over design to gather preliminary data on how a common genetic risk allele may influence their response to these medications. The study seeks to address the variability in treatment response and improve the understanding of genetic factors contributing to AF. Ultimately, this research could pave the way for more personalized treatment strategies for patients with AF.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥ 18 years of age
* History of typical or early-onset symptomatic (≥2 episodes/month) paroxysmal/persistent AF
* ECG that was recorded within 1 month of randomization showing AF
* Eligible for both Flecainide(Class I) and Sotalol (Class III) AAD
* Able to give informed consent

Exclusion Criteria:

* Permanent AF or isolated atrial flutter
* Cardiac or thoracic surgery within the previous 6 months
* Previous use of amiodarone other than short-term use (e.g. for an acute arrhythmia in hospital)
* Medical condition that is likely to be fatal in less than one year
* A history of prior AF ablation
* Have already been tried on 2 or more AADs in the past for AF
* Creatinine clearance \<40 ml/min
* Left ventricular ejection fraction \< 50%
* Contra-indication to a Class I AAD e.g., structural heart disease, or history of MI
* Contra-indication to a Class III AAD, e.g., congenital or acquired long QT syndrome with QTc\>480 ms in females and \>460 ms in males at baseline
* A reversible cause of AF (e.g., hyperthyroidism)
* Females who are pregnant or nursing
* History of severe AV node dysfunction unless an electronic pacemaker is present
* First- or second-degree relative has already participated in the study
* Unable to adhere to study procedures that are strictly for research purposes

Where it's running

• University of Illinois at Chicago
  Chicago, Illinois, United States Recruiting
• Jesse Brown VA Medical Center
  Chicago, Illinois, United States Not yet recruiting
• Rush University Medical Center
  Chicago, Illinois, United States Not yet recruiting
• Advocate Christ Medical Center
  Oak Lawn, Illinois, United States Not yet recruiting

Study contacts

• Study coordinator: Dawood Darbar, M.D.
• Email: darbar@uic.edu
• Phone: 6158879032

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.