Testing airway responsiveness in healthy adults using methacholine
Methacholine Challenge Test (MCT) in Healthy Adults: Oscillometry Measured Alone Compared to Oscillometry and FEV1 During the Same Test
This study is testing how healthy adults respond to a breathing test with methacholine to learn more about how their airways work.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 25 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Allergi- og Lungeklinikken, Elsinore Research network |
| Locations | 1 site (Elsinore) |
| Trial ID | NCT06509659 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the Methacholine Challenge Test (MCT) and Impedance Oscillometry (IOS) in healthy adults to better understand airway hyperreactivity. The study will assess small airway dysfunction by measuring respiratory resistance and reactance, focusing on the differences between total and proximal airway resistance. By including healthy controls, the study seeks to fill a gap in existing research, which has primarily focused on patients with asthma. The findings may provide insights into the role of small airways in respiratory health.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults with normal lung function and no history of lung disease.
Not a fit: Patients with existing lung diseases, lung symptoms, or those who smoke may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of airway responsiveness and improve diagnostic approaches for respiratory conditions.
How similar studies have performed: While there have been limited studies on this topic, the approach of combining MCT and IOS in healthy adults is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Forced expiratory volume in the 1. second (FEV1) \>80% * FEV1/FVC-ratio \>0,7 * FeNO \<25 pbb * Oxygen saturation (SatO2) \>95% * Negative methacholine Challenge Test = drop in FEV1 less than 20% Exclusion Criteria: * Any lung disease * Lung symptoms * Medicine for lung disease * Tobacco smoking * Ex-smokers with more than 5 package years * BMI (body mass index) \>40 kg/m2
Where this trial is running
Elsinore
- Thomas Ringbæk — Elsinore, Denmark (Recruiting)
Study contacts
- Principal investigator: Thomas J Ringbæk — Allergy and Lung Clinic Elsinore
- Study coordinator: Thomas Ringbæk, MSci
- Email: thomasringbaek@gmail.com
- Phone: 21969087
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.