Testing a niacinamide cosmetic product for treating irritant contact dermatitis
Randomized Controlled Trial of Niacinamide Cosmetic Product Efficacy in Model of Irritant Contact Dermatitis
This study is testing if a niacinamide cream can help treat irritant contact dermatitis by comparing it to a placebo in healthy volunteers.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | University of Split, School of Medicine Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Split) |
| Trial ID | NCT06331390 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness and safety of a niacinamide cosmetic product in treating irritant contact dermatitis. Healthy volunteers will participate in a randomized, controlled trial where sodium lauryl sulfate is used to induce dermatitis on their forearms. The efficacy will be measured over a period of 7 days using specialized devices to assess hydration, redness, and transepidermal water loss. Participants will be divided into groups receiving either the niacinamide product or a placebo.
Who should consider this trial
Good fit: Ideal candidates for this study are young, healthy volunteers without any skin diseases or damage.
Not a fit: Patients with existing skin diseases, recent use of corticosteroids or immunomodulators, or those who are pregnant or lactating may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new topical treatment option for individuals suffering from irritant contact dermatitis.
How similar studies have performed: While there have been studies on the effects of niacinamide in skincare, this specific approach to irritant contact dermatitis is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * young, healthy volunteers who gave written informed consent Exclusion Criteria: * skin disease, skin damage on measurement sites, use of corticosteroids and immunomodulators a month prior to the inclusion and during the trial, non-adherence to the trial protocol, exposure to artificial UV radiation, pregnancy and lactation
Where this trial is running
Split
- University of Split School of Medicine — Split, Croatia (Recruiting)
Study contacts
- Principal investigator: Josipa Bukić — Ussm
- Study coordinator: Josipa Bukić
- Email: jbukic@mefst.hr
- Phone: 00385917933752
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.