Testing a new pneumococcal vaccine in healthy infants
A Phase 3, Randomized, Modified Double-blind, Active-controlled, Parallel-group, 2-arm Study to Investigate the Safety and Immunogenicity of a 21-valent Pneumococcal Conjugate Vaccine in Healthy Infants and Toddlers
This study is testing a new pneumococcal vaccine for healthy infants to see if it helps their bodies build better protection against pneumonia-causing bacteria compared to an existing vaccine.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 1080 (estimated) |
| Ages | 42 Days to 112 Days |
| Sex | All |
| Sponsor | Sanofi Industry-sponsored |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Bydgoszcz, Kujawsko-pomorskie) |
| Trial ID | NCT06975878 on ClinicalTrials.gov |
What this trial studies
This Phase 3 clinical trial evaluates the safety and immunogenicity of the investigational 21-valent pneumococcal conjugate vaccine (PCV21) compared to the licensed 15-valent vaccine (Vaxneuvance) in healthy infants aged approximately 2 months. Participants will receive the vaccines alongside routine pediatric vaccinations at specified intervals over a period of up to 20 months. The study aims to determine how well the body develops antibodies against pneumococcal bacteria after vaccination. The trial includes both full-term and preterm infants, with specific visit schedules for each group.
Who should consider this trial
Good fit: Ideal candidates are healthy infants aged 42 to 112 days, either full-term or medically stable preterm infants.
Not a fit: Patients with known immunodeficiencies or a history of pneumococcal infections may not benefit from this study.
Why it matters
Potential benefit: If successful, this vaccine could enhance protection against pneumococcal infections in infants.
How similar studies have performed: Other studies of pneumococcal vaccines have shown success, indicating a promising approach for immunization.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 42 to 112 days on the day of inclusion * Participants who are healthy as determined by medical evaluation including medical history and physical examination * Born at full term of pregnancy (≥ 37 weeks) and with a birth weight ≥ 2.5 kg or born after a gestation period above 28 (\> 28 weeks) through 36 weeks with a birth weight ≥ 1.5 kg, and in both cases medically stable as assessed by the investigator Exclusion Criteria: Participants are excluded from the study if any of the following criteria apply: * Known or suspected congenital or acquired immunodeficiency; or receipt of immunosuppressive therapy, such as anti-cancer chemotherapy or radiation therapy; or long-term systemic corticosteroid therapy * History of microbiologically confirmed Streptococcus pneumoniae infection or disease * Any contraindication to the routine pediatric vaccines being administered in the study * History of seizure or significant stable or progressive neurological disorders such as infantile spasms, inflammatory nervous system diseases, encephalopathy, cerebral palsy * Known systemic hypersensitivity to any of the study interventions components, or history of a life-threatening reaction to the study interventions used in the study or to a product containing any of the same substances * Laboratory-confirmed or known thrombocytopenia, as reported by the parent/legally acceptable representative (LAR), contraindicating intramuscular (IM) injection * Bleeding disorder, or receipt of anticoagulants in the 3 weeks preceding inclusion, contraindicating IM injection * Chronic illness that, in the opinion of the investigator, is at a stage where it might interfere with study conduct or completion * Moderate or severe acute illness/infection (according to investigator judgment) or febrile illness (temperature ≥ 38.0°C \[≥ 100.4°F\]) on the day of study intervention administration. A prospective participant should not be included in the study until the condition has resolved or the febrile event has subsided. * Receipt of any vaccine in the 4 weeks preceding the study intervention administration or planned receipt of any vaccine in the 4 weeks following the study intervention administration, except for oral rotavirus vaccine, which may be received anytime during the study including at study visits and for influenza vaccination or meningococcal b vaccine, which may be received at least 14 days before or 14 days after any study vaccination. This exception includes monovalent pandemic influenza vaccines and multivalent influenza vaccines, as applicable per local recommendations. * Previous vaccination against S. pneumoniae * Previous vaccination against the following antigens: diphtheria, tetanus, pertussis, Haemophilus influenzae type b, and poliovirus * Receipt of more than 1 dose of hepatitis B vaccine * Receipt of immune globulins, blood or blood-derived products since birth * Participation at the time of study enrollment (or in the 6 weeks preceding the first study intervention administration) or planned participation during the present study period in another clinical study investigating a vaccine, drug, medical device, or medical procedure Note: The above information is not intended to contain all considerations relevant to a potential participation in a clinical trial.
Where this trial is running
Bydgoszcz, Kujawsko-pomorskie
- Investigational Site Number : 6160001 — Bydgoszcz, Kujawsko-pomorskie, Poland (Recruiting)
Study contacts
- Study coordinator: Trial Transparency email recommended (Toll free for US & Canada)
- Email: contact-us@sanofi.com
- Phone: 800-633-1610
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.