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Clinical trial No longer in our active list Interventional Ages 18 and up

Testing a new device for monitoring epilepsy seizures

Official title: Real World Testing and Cost-effectiveness Analysis of Subcutaneous EEG (REAL-ASE)

Run by King's College London · NCT06144047 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing a new device that monitors seizures in people with epilepsy to see if it works better than keeping a diary of seizures.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment33 (estimated)
SponsorKing's College London
Academic / other
Locations1 site (London)
Trial IDNCT06144047 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults with treatment-resistant epilepsy who experience at least 10 seizures per year and are willing to use a smartphone for an electronic seizure diary.

Probably not a fit

Patients with psychogenic non-epileptic attacks or those with frequent involuntary movements may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of a minimally-invasive subcutaneous EEG device, UNEEG™ SubQ, in accurately counting epileptic seizures compared to traditional participant-reported seizure diaries. Over six months, 33 participants with drug-resistant epilepsy will have the device implanted to collect continuous EEG data, which will be analyzed and communicated to their clinicians. The study aims to assess the feasibility and acceptability of this method, its impact on quality of life, and potential cost-effectiveness for the healthcare system.

Why it matters

Potential benefit: If successful, this approach could lead to more accurate seizure monitoring and improved management of epilepsy, enhancing patients' quality of life.

How similar studies have gone: Other studies have shown promise in using wearable devices for seizure monitoring, but this specific approach with subcutaneous EEG is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Key Inclusion Criteria:

* Have given written informed consent
* Diagnosis of treatment-resistant epilepsy of any syndrome in which seizures are detectable in scalp EEG with two electrodes.
* Adults (≥18 years of age)
* Participant routinely keeps a seizure diary, has a smartphone and is willing to use the electronic diary for the study.
* Experiencing ≥10 seizures per year according to their existing seizure diary.
* Willing and able to comply with study procedures

Key Exclusion Criteria:

* Established current diagnosis of psychogenic non-epileptic attacks (dissociative seizures)
* Frequent vigorous involuntary movements (eg. chorea, athetosis) or frequent parasomnias with major motor components (eg. sleep walking, night terrors)

Where it's running

  • King's College London
    London, United Kingdom     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Epilepsy 491King's College London 42
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.