Testing a method to detect exercise-induced laryngeal obstruction
Feasibility of Constant Work Rate Testing to Detect Exercise-induced Laryngeal Obstruction
Bispebjerg Hospital · NCT05558020
This study is trying to see if a specific exercise test can help find out if adults have exercise-induced laryngeal obstruction while they work out.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Bispebjerg Hospital (other) |
| Locations | 1 site (København NV, Region Hovedstaden) |
| Trial ID | NCT05558020 on ClinicalTrials.gov |
What this trial studies
This observational pilot study aims to evaluate the feasibility of using constant work rate testing to induce and detect exercise-induced laryngeal obstruction (EILO) in adult patients. Participants will undergo continuous laryngoscopy during exercise while following an incremental exercise protocol. The study will assess whether different work rates can sufficiently provoke EILO symptoms, providing insights into the condition's diagnosis and management.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with a clinical suspicion of having EILO, including those with well-controlled asthma.
Not a fit: Patients who do not exhibit EILO in standard clinical tests or have significant comorbidities that could confound results may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the diagnostic accuracy for patients suffering from exercise-induced laryngeal obstruction.
How similar studies have performed: While this approach is innovative, similar studies have not been widely reported, indicating that this may be a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 or above with a clinical suspicion of having EILO. * Individuals with concurrent asthma can participate in the study provided that their asthma is well-controlled, determined by a negative bronchoprovocation test. Exclusion Criteria: * No EILO found in Clinical standard-of-care CLE test * Not able to complete the exercise test for other reasons than breathlessness or leg fatigue (e.g. injury, disease or disability preventing cycling to maximal exertion). * Comorbidities other than asthma, which, judged by the investigator, might confound the test results or pose a medical risk to the patient (e.g. cardiac disease, exercise-induced anaphylaxis). * Current smokers (\< 6 months of stopping) or individuals with a significant smoking history (\>10 pack years). * Pregnancy.
Where this trial is running
København NV, Region Hovedstaden
- Bispebjerg Hospital — København NV, Region Hovedstaden, Denmark (RECRUITING)
Study contacts
- Study coordinator: Emil Walsted, MD, PhD
- Email: emil.ingerslev.walsted@regionh.dk
- Phone: +4530338750
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Exercise-induced Laryngeal Obstruction