Tegileridine plus intercostal nerve block for pain after thoracoscopic lung removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center interventional study at Tongji Hospital combines an early intercostal nerve block (ICNB) with patient-controlled intravenous tegileridine to cover both immediate incision pain and later central/visceral pain after thoracoscopic lung resection. Patients receive perioperative ICNB and postoperative patient-controlled analgesia with tegileridine, with interventions listed to include sufentanil as a comparator or reference analgesic. The approach aims to provide rapid incision analgesia from the block and sustained central analgesia from tegileridine while reducing common opioid side effects. Primary outcomes will focus on postoperative pain scores, opioid consumption, recovery metrics, and incidence of chronic post-surgical pain.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age range: 18 to 75 years old;
* Patients undergoing elective thoracoscopic lobectomy or segmentectomy;
* ASA classification levels I-III;
* BMI 18 \~ 30 kg/m2。
* Voluntarily participate and sign an informed consent form.

Exclusion Criteria:

* Patients with preoperative alcohol dependence and long-term use of analgesic drugs are receiving analgesic treatment for other acute and chronic pain;
* Pregnant or lactating women;
* Allergies or other contraindications to the anesthetics, analgesics, and antiemetic drugs used in the study;
* Patients with severe sleep apnea syndrome or acute or severe bronchial asthma;
* Suffering from mental and neurological disorders or cognitive impairment, known or suspected gastrointestinal obstruction, severe liver and kidney dysfunction (Child Pugh score C), chronic obstructive pulmonary disease or severe cardiovascular disease, etc;
* Researchers consider participants who are not suitable to participate in this study and those who refuse to participate.

Where it's running

• Tongji hospital
  Wuhan, Hubei, China Recruiting

Study contacts

• Study coordinator: Aijun Xu, Dr.
• Email: ajxu@tjh.tjmu.edu.cn
• Phone: 18627784217

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.