tDCS plus cognitive training to improve thinking in persistent post-concussion syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The program enrolls adults (≥18) with a confirmed mild traumatic brain injury 1–6 years prior who continue to have cognitive symptoms and can communicate in Chinese. Participants receive repeated sessions of transcranial direct current stimulation (tDCS) paired with a structured cognitive training program delivered in-person. Cognitive performance and brain measures (fMRI and magnetic resonance spectroscopy) are collected before and after the intervention to track changes in cognition, cortical connectivity, and excitatory/inhibitory balance. Key exclusions include other neurological or psychiatric disorders, implanted devices, pregnancy, recent medical instability, and inability to tolerate MRI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* being 18 years old or older;
* having a history of a mild TBI (less than 30 minutes loss of consciousness) 1-6 years prior to the study;
* able to communicate in Chinese.

Exclusion Criteria:

* being without a confirmed diagnosis from the medical practitioner;
* having a history of other neurological and psychiatric disorders, skull defect, recent medical instability (within 3 weeks);
* being pregnant;
* being medication for a psychiatric condition (e.g., major depression, anxiety, schizophrenia);
* with any implanted devices or suffering from real claustrophobia or feel uncomfortable in small, enclosed spaces, like MRI tunnel

Where it's running

• The Hong Kong Polytechnic University
  Hung Hom, Kowloon, Hong Kong Recruiting

Study contacts

• Principal investigator: Yvonne Han, PhD — The Hong Kong Polytechnic University
• Study coordinator: Yvonne Han, PhD
• Email: yvonne.han@polyu.edu.hk
• Phone: +852 2766 7578

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.