Taurine to prevent radiation-induced mouth sores and skin reactions

Inclusion Criteria:

1. Patients voluntarily joined the study, were informed of the purpose and process of the study, signed the informed consent form, and were willing and able to abide by the study protocol.
2. Aged 18 to 80, with no gender restrictions.
3. Patients that require radiotherapy after surgery for oral/oropharyngeal cancer. After evaluation by the radiation oncologist, radiotherapy at 30 sessions /60Gy is planned.
4. The expected survival period is more than 6 months.
5. No radiotherapy for the head and neck has been performed in the past, and no other medications that affect the results of this trial have been used. No chemotherapy or immunotherapy was performed within one month before the beginning of the trial.

Exclusion criteria:

1. Uncontrollable local or systemic infections of the oral cavity and head and neck.
2. Active or history of autoimmune diseases; Diseases requiring systemic steroid hormones or immunosuppressive medications.
3. Bleeding occurred within 3 months before enrollment, including but not limited to: gastrointestinal bleeding caused by gastric fundus or esophageal varices, increased risk of bleeding caused by portal hypertension, active gastrointestinal bleeding, etc. Or there is a risk of major bleeding as assessed by the researcher.
4. Arterial/venous thrombosis that occurred within 6 months prior to the screening, such as cerebrovascular accidents, deep vein thrombosis and pulmonary embolism, etc.
5. Interstitial pneumonia or active pneumonia with clinical significance, or other respiratory diseases that seriously affect lung function.
6. History of cardiovascular diseases, including but not limited to: (1) Congestive heart failure (NYHA grade \> 2); (2) Unstable angina pectoris; (3) Myocardial infarction occurred in the past three months; (4) Any supraventricular arrhythmia or ventricular arrhythmia that requires treatment or intervention.
7. Severe endocrine or hematopoietic system diseases (such as diabetes, leukemia, etc.), gastrointestinal obstruction, active bleeding, gastric perforation and other conditions.
8. Combined with malignant tumors of other organs.
9. Intractable or refractory epilepsy, with a large amount of pleural effusion, ascites, pericardial effusion, etc. that cannot be controlled by medicines.
10. History of HIV, syphilis, active hepatitis, active pulmonary tuberculosis, active EBV and/or CMV infection within one year before screening, or those with a history of active pulmonary tuberculosis infection for more than one year without regular treatment; active hepatitis B or C. Patients with positive HBsAg or HBcAb can participate in this study if the HBV DNA test is below the lower limit of the normal value detected by the research center; patients with positive HCV antibody can participate in this study if the HCV RNA test is below the lower limit of the normal value detected by the research center.
11. History of allogeneic bone marrow transplantation or solid organ transplantation.
12. Have received cell therapy products that have undergone genetic modification or editing in the past.
13. Have previously used medicines that can cause medication-related osteonecrosis of the jaw.
14. Have taken drugs containing taurine within one month before randomization in this study.
15. Allergic to taurine.
16. Patients who, in addition to radiotherapy, requires chemotherapy or immunotherapy simultaneously.
17. Mental illness, alcohol abuser, drug user or drug abuser.
18. Pregnant or lactating women; Women who plans to become pregnant within half a year after treatment.
19. Poor compliance or other circumstances assessed by the researcher as unsuitable for participation in this clinical study.