Taste stimulation to improve swallowing in post-stroke patients
Effects of Taste Stimulation on Swallowing Function of Patient With Post-stroke Dysphagia and Its Mechanism
This study is testing if using favorite or sour tastes can help improve swallowing in people who have trouble swallowing after a stroke.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 87 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Qilu Hospital of Shandong University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 2 sites (Jinan, Shandong and 1 other locations) |
| Trial ID | NCT05989100 on ClinicalTrials.gov |
What this trial studies
This clinical study aims to compare the effects of favorite taste stimulation and sour taste stimulation on swallowing function in post-stroke patients with dysphagia. Participants will undergo evaluations and treatments over two weeks, receiving either taste stimulation or traditional thermal stimulation. The study will also utilize functional near-infrared spectroscopy (fNIRS) to explore the neural mechanisms involved in taste stimulation and its impact on swallowing. Assessments will be conducted before and after treatment to measure improvements in swallowing capabilities.
Who should consider this trial
Good fit: Ideal candidates are individuals who have experienced a first-ever stroke and have been diagnosed with dysphagia lasting more than one month.
Not a fit: Patients with other conditions causing dysphagia or those who have lost taste perception may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance swallowing function and quality of life for patients suffering from post-stroke dysphagia.
How similar studies have performed: While taste stimulation has been explored in various contexts, this specific approach targeting post-stroke dysphagia is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. diagnosed as first-ever stroke and diagnosed as dysphagia with modified water swallowing test, duration of dysphagia was more than one month; 2. can complete all the test with MMSE \>15; 3. agree to participate the experiment, and sign the written informed consent. Exclusion Criteria: 1. have other diseases that could induce dysphagia, such as cranial and neck tumor, history of radiotherapy or chemotherapy, tongue muscle atrophy, myasthenia gravis, parotid tumor and multiple sclerosis, etc; 2. lose of taste perception; 3. combined with other major disease that can not tolerate the examination and swallowing training; 4. surgery of cranial allogeneic plasticity, scalp ulcer or damage that thought as contraindications of fNIRS. 5. with other neurological conditions (eg, Parkinson's disease, dementia).
Where this trial is running
Jinan, Shandong and 1 other locations
- Qilu hospital of Shandong University — Jinan, Shandong, China (Recruiting)
- Yonghui Wang — Jinan, Shandong, China (Not_yet_recruiting)
Study contacts
- Principal investigator: Yonghui Wang, professor — Qilu Hospital of Shandong University
- Study coordinator: Yonghui Wang, professor
- Email: yonghuiwangphd@163.com
- Phone: 86-18560083581
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.