Targeting blood pressure rhythms in obese individuals
Official title: Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood Pressure
Run by University of Alabama at Birmingham · NCT04971720 · Data updated 2026-11-12
This study is testing if giving blood pressure medications at certain times can help people with obesity and high blood pressure feel better and manage their condition more effectively.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 160 (estimated) |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Locations | 1 site (Birmingham, Alabama) |
| Status | Recruiting |
| Started | February 18, 2022 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2027 |
| Registry record updated | April 9, 2026 |
| Trial ID | NCT04971720 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are obese adults aged 18 and older with specific blood pressure measurements and a body mass index between 30 to 45 kg/m².
✕Probably not a fit
Patients with a history of cardiovascular diseases or those taking multiple antihypertensive medications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the relationship between natriuretic peptides and blood pressure rhythms in obese individuals, who often experience nocturnal hypertension. It aims to synchronize antihypertensive therapy with the body's natural biological rhythms to improve blood pressure control. The study will utilize medications that enhance natriuretic peptide levels and inhibit the renin-angiotensin-aldosterone system, administered at specific times to optimize their effects. By focusing on the timing of medication, the researchers hope to address the unique challenges faced by obese patients with hypertension.
Why it matters
Potential benefit: If successful, this approach could significantly improve blood pressure control and reduce cardiovascular risks in obese patients.
How similar studies have gone: While the approach of synchronizing medication with biological rhythms is innovative, similar studies have shown promise in managing hypertension, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age more than or equal to 18 years of age * Body Mass Index between 30 to 45 kg/m\^2 * Blood pressure: Systolic BP more than or equal to 130mmHg and less than or equal to 160mmHg and diastolic blood pressure more than or equal to 80mmHg and less than or equal to 100mmHg. Individuals with hypertension as per the 2017 ACC/AHA Guidelines will be eligible for enrollment Exclusion Criteria: * Age less than 18, at screening. * Systolic BP \<130 or \>160mmHg at baseline, or diastolic BP \<80 or \>100 mmHg at baseline * BMI \<30 kg/m\^2 or \>45 kg/m\^2 * History of pulmonary hypertension * Have any past or present illness of cardiovascular disease including myocardial infarction, angina, cardiac arrhythmia, diabetes, stroke, TIA, or seizure. * Participants who are taking 3 or more classes of hypertension medications on the maximum dose or with resistant hypertension * History of angioedema * Estimated glomerular filtration rate (GFR) \< 60 ml/min/1.73 m2 (CKD-EPI equation); urine albumin creatinine ratio ≥30 mg/g * Hepatic Transaminase (AST and ALT) levels \>3x the upper limit of normal; * Significant psychiatric illness * Anemia (men, Hct \< 38%; women, Hct \<36%) * Participants working night shifts or swing shifts * Women who are pregnant or breastfeeding or who can become pregnant and not practicing an acceptable method of birth control during the study (including abstinence)
Where it's running
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University of Alabama at Birmingham
Birmingham, Alabama, United States Recruiting
Study contacts
- Principal investigator: Pankaj Arora, MD, FAHA — University of Alabama at Birmingham
- Study coordinator: Nehal Vekariya, MS
- Email: nvekariya@uabmc.edu
- Phone: 205-934-7173
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.