Clinical trial Recruiting at 1 site Phase 2 Interventional Ages 16 to 99

Targeted therapy for rare cancers

Official title: The MATRIX Clinical Studies of Precision Cancer Therapy for Rare Cancers

Run by Oslo University Hospital · NCT06119789 · Data updated 2026-11-12

This study is testing whether a personalized cancer treatment based on specific gene changes can help people with rare and hard-to-treat cancers feel better and improve their outcomes.

Quick facts

PhasePhase 2
Study typeInterventional
Ages16 Years to 99 Years
SexAll
Enrollment96 (estimated)
SponsorOslo University Hospital
Academic / other
Locations1 site (Oslo)
StatusRecruiting
StartedMarch 20, 2025
Main results expectedNovember 30, 2033
Study endsAugust 1, 2036
Registry record updatedMarch 26, 2025
Trial IDNCT06119789 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients with rare malignant neoplasms who have identified biomarkers and an ECOG performance status of 0-2.

Probably not a fit

Patients with serious other diseases or an ECOG performance status of 3-5 may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients with rare malignant neoplasms who may benefit from precision cancer therapy. It employs advanced molecular diagnostics to identify targetable alterations in tumor cells by analyzing over 500 genes at the DNA and RNA levels. Based on these molecular characteristics, patients will receive targeted treatments such as Imatinib, Trametinib, or Dabrafenib. The goal is to improve treatment outcomes for patients with hard-to-treat cancers.

Why it matters

Potential benefit: If successful, this approach could significantly improve treatment options and outcomes for patients with rare cancers.

How similar studies have gone: Other studies have shown promise in using targeted therapies for specific molecular alterations in cancers, indicating a potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* ECOG 0-2,
* identified biomarker,
* reasonable biochemistry

Exclusion Criteria:

* ECOG 3-5
* serious other diseases

Where it's running

  • Oslo University Hospital
    Oslo, Norway
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.