Targeted therapy for rare cancers
Official title: The MATRIX Clinical Studies of Precision Cancer Therapy for Rare Cancers
Run by Oslo University Hospital · NCT06119789 · Data updated 2026-11-12
This study is testing whether a personalized cancer treatment based on specific gene changes can help people with rare and hard-to-treat cancers feel better and improve their outcomes.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 16 Years to 99 Years |
| Sex | All |
| Enrollment | 96 (estimated) |
| Sponsor | Oslo University Hospital Academic / other |
| Locations | 1 site (Oslo) |
| Status | Recruiting |
| Started | March 20, 2025 |
| Main results expected | November 30, 2033 |
| Study ends | August 1, 2036 |
| Registry record updated | March 26, 2025 |
| Trial ID | NCT06119789 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with rare malignant neoplasms who have identified biomarkers and an ECOG performance status of 0-2.
✕Probably not a fit
Patients with serious other diseases or an ECOG performance status of 3-5 may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on patients with rare malignant neoplasms who may benefit from precision cancer therapy. It employs advanced molecular diagnostics to identify targetable alterations in tumor cells by analyzing over 500 genes at the DNA and RNA levels. Based on these molecular characteristics, patients will receive targeted treatments such as Imatinib, Trametinib, or Dabrafenib. The goal is to improve treatment outcomes for patients with hard-to-treat cancers.
Why it matters
Potential benefit: If successful, this approach could significantly improve treatment options and outcomes for patients with rare cancers.
How similar studies have gone: Other studies have shown promise in using targeted therapies for specific molecular alterations in cancers, indicating a potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ECOG 0-2, * identified biomarker, * reasonable biochemistry Exclusion Criteria: * ECOG 3-5 * serious other diseases
Where it's running
-
Oslo University Hospital
Oslo, Norway Recruiting
Study contacts
- Study coordinator: Åslaug Helland, MD PhD
- Email: ahelland@medisin.uio.no
- Phone: +4795940863
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.