Targeted resuscitation approach for septic shock patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates a personalized resuscitation strategy for patients experiencing septic shock by utilizing hemodynamic phenotyping and capillary refill time (CRT) as key indicators. The approach aims to tailor fluid and medication administration based on individual patient responses rather than applying a standard treatment protocol. By analyzing various clinical parameters, the study seeks to reduce organ dysfunction and mortality rates associated with septic shock. The methodology builds on previous findings from the ANDROMEDA-SHOCK trial, which indicated that CRT-targeted resuscitation could improve patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Consecutive adult patients (≥ 18 years)
* Patients with septic shock according to Sepsis-3 consensus conference. In short, septic shock is defined as suspected or confirmed infection, plus hyperlactatemia and NE requirements due to persistent hypotension, after a fluid load of at least 1000mL in 1h
* Patient and/or relative informed and having signed the information and consent form for participation in the study

Exclusion Criteria:

* More than 4 hours since septic shock diagnosis,
* Anticipated surgery or acute hemodialysis procedure to start during the 6h intervention period
* Active bleeding,
* Do not resuscitate status,
* Child B-C Cirrhosis
* Underlying disease process with a life expectancy \< 90 days and/or the attending clinician deems aggressive resuscitation unsuitable
* Refractory shock (high risk of death within 24h)
* Pregnancy
* Concomitant severe acute respiratory distress syndrome
* Patients in whom CRT cannot be accurately assessed
* Non-affiliation to a social security scheme or to another social protection scheme
* Patient on AME (state medical aid) (unless exemption from affiliation
* Patient under legal protection (guardianship, curatorship)
* Participation in another interventional study involving human participants or being in the exclusion period at the end of a previous study involving human participants, if applicable
* Inability, according to the investigator, to understand the study (non-French-speaking patient, cognitive disorders)

Where it's running

• Hôpital Robert Debré, Université de Reims
  Reims, France Recruiting

Study contacts

• Study coordinator: Olfa MD Hamzaoui, PhD
• Email: ohamzaoui@chu-reims.fr
• Phone: 0033310736973

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.