Targeted medical therapy for angina with non-obstructive coronary arteries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of targeted medical therapy in improving symptoms and quality of life for patients suffering from angina and non-obstructive coronary arteries. Participants will receive either active medication or a placebo for a duration of four weeks, following a drug titration phase. The study will assess the impact of these treatments through questionnaires measuring quality of life before and after the intervention, after confirming the cause of chest pain through coronary function testing.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients with stable angina referred to the Stanford University Hospital cardiac catheterization laboratory for clinically indicated coronary function testing are eligible for inclusion into the study.

Specific inclusion criteria for randomization:

* Absence of significant epicardial coronary artery disease on angiography
* Fractional flow reserve \> 0.80

And ≥ 1 of the following:

* Epicardial coronary spasm on acetylcholine testing
* Microvascular spasm on acetylcholine testing
* Coronary flow reserve \< 2.5
* Index of microcirculatory resistance ≥ 25
* Myocardial bridge on intravascular ultrasound with dobutamine resting full-cycle ratio ≤ 0.76

Exclusion Criteria:

* Acute coronary syndrome less than one week prior to enrolment
* Cardiomyopathy
* Contraindications to beta-blockers or calcium channel blockers
* Baseline systolic blood pressure \< 95 mmHg
* Baseline heart rate \< 55 bpm

Where it's running

• Stanford Hospital
  Palo Alto, California, United States Recruiting

Study contacts

• Principal investigator: Jennifer Tremmel, MD — Stanford University
• Study coordinator: Christopher Wong, MBBS, PhD
• Email: ccywong@stanford.edu
• Phone: (650) 725 5909

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.