Tailored treatment for patients with acute diverticulitis and abscesses
Towards a Tailored Approach for Patients With Acute Diverticulitis and Abscess Formation. A Multicenter Cohort Analysis
This study is testing if treating patients with acute diverticulitis and abscesses using antibiotics and drainage works well and helps avoid complications.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Cagliari Academic / other |
| Locations | 1 site (Cagliari) |
| Trial ID | NCT06109506 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients diagnosed with acute diverticulitis who have radiological evidence of contained perforation. It aims to analyze the effectiveness of conservative treatment approaches, including antibiotic therapy and percutaneous drainage, in managing diverticular abscesses. The study seeks to understand the incidence of treatment failure in patients managed conservatively, which could lead to improved treatment strategies. By gathering data from multiple centers, the study hopes to provide insights into the best practices for treating this condition.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older diagnosed with acute diverticulitis and radiological findings of contained perforation.
Not a fit: Patients with perforated diverticulitis with peritonitis or those requiring immediate surgical intervention will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatment strategies for patients with acute diverticulitis and abscess formation.
How similar studies have performed: While there is limited high-quality evidence regarding the treatment of diverticular abscesses, similar observational studies have shown promise in understanding conservative management approaches.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adult (≥18 years of age) patients 2. Patients diagnosed with acute diverticulitis with radiological findings of contained perforation (modified Hinchey classification Ib and IIa/b). 3. Patients who are initially managed conservatively according to contemporary guidelines. Exclusion Criteria: 1. Patients with perforated diverticulitis with peritonitis (Hinchey III or IV stages). 2. Patients with clinically assessed generalized peritonitis. 3. Patients diagnosed with colonic cancer mimicking acute diverticulitis with abscess. 4. Requirement for urgent or emergent surgery decided immediately following hospital admission.
Where this trial is running
Cagliari
- University of Cagliari Hospital — Cagliari, Italy (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.