Tailored diuretic treatment for patients with acute heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates a tailored diuretic algorithm based on urinary sodium levels in patients with acutely decompensated heart failure. The study aims to determine if this personalized approach can lead to faster and more complete decongestion compared to standard care, ultimately improving patient outcomes. Participants will be randomly assigned to receive either the tailored treatment or usual care, with their responses monitored to assess effectiveness and safety. The trial is designed to provide evidence for implementing urinary sodium as a biomarker in diuretic therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18 years;
* HF (HFrEF, HFmrEF or HFpEF) diagnosed according to the 2021 HF Guidelines of the European Society of Cardiology \[5\];
* Presentation with AHF meaning at least one symptom (dyspnea, orthopnea, or edema) and one sign (rales, peripheral edema, ascites, or pulmonary vascular congestion on chest radiography) of AHF;
* An elevated NT-proBNP \>300pg/ml;
* Requiring the need for iv diuretics.

Exclusion Criteria:

* Terminal renal insufficiency defined as: dialysis patients or eGFR (estimated glomerular filtration rate) \< 10 mL/min/1.73 m2;
* Patients included in other investigational studies regarding heart failure.
* Presentation with cardiogenic shock or respiratory insufficiency or another reason requiring admission to the intensive care unit upon admission (IC transfer later in the hospitalization is not an exclusion).

Where it's running

• Zuyderland MC
  Heerlen, Limburg, Netherlands Recruiting
• Amphia ziekenhuis
  Breda, North Brabant, Netherlands Recruiting

Study contacts

• Study coordinator: Sandra van Wijk, MD, PhD
• Email: s.vanwijk@zuyderland.nl
• Phone: 088 - 459 9701

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.