Synbiotic-enriched multi-nutrient supplement plus supervised exercise to improve longevity-related health markers in pre-frail adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-arm, open-label, single-centre study will enroll 40 prefrail men and women aged 50–80 in Singapore to receive a 12-week supervised exercise program alongside a synbiotic-enriched multi-nutrient oral supplement. Outcomes include measures of muscle mass and strength, gut microbiome composition, immune biomarkers, cognitive performance, and biological age markers measured before and after the intervention. Eligible participants must be Singapore residents with BMI ≥18 and meet Fried criteria for prefrailty, and they must avoid specified prebiotic/probiotic supplements and restrictive diets during the trial. The study will explore whether combining targeted nutrition with supervised exercise can produce measurable shifts across multiple ageing-related systems over a short intervention period.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. Singapore residents of all ethnic groups
2. Adults aged 50-80 years (both male and female)
3. Body mass index (BMI) ≥18 kg/m²
4. Classified as Prefrailty according to Fried frailty criteria
5. Willing and able to attend all data collection visits and to comply with the exercise and supplementation protocols.
6. Able and willing to provide written informed consent.

Exclusion Criteria:

1. Current use of supplements containing: Bifidobacterium longum 536 (BB536) like Kordel's BB536 bifidus; Bifidobacterium longum such as GniiB immunity; GOS (Galacto-oligosaccharides); FOS (Fructo-oligosaccharides); Inulin or any commercial healthy-aging powdered milk products
2. BMI \>30 kg/m2 3 Being on special diets including but not limited to ketogenic diets or diets prescribed by a healthcare professional

4\. Received any vaccination within the past 8 weeks. 5. Inition of new medication or use of medications affecting gastrointestinal function within the past 8 weeks, including but not limited to antibiotics or Proton pump inhibitors 6. Known allergies or intolerances, including, soy allergy; fibre allergy (e.g., GOS) or requirement for a fibre-free diet; fish allergy; Cow's milk protein allergy or lactose intolerance; galactosaemia 7. More than two unstable chronic conditions (e.g., hypertension, diabetes, hyperlipidemia, osteoarthritis, COPD) 8. Medical conditions for which probiotic use is contraindicated, including but not limited to immunocompromised individuals, astrointestinal failure or severe gastrointestinal disturbances (e.g., blood in stool), presence of a central venous catheter, open wounds following surgery 9. Contraindications to oral feeding, including gastrointestinal failure, complete intestinal obstruction, inability to access the gut or high loss intestinal fistulae 10. Known renal disease were unable to tolerate 2 servings per day. 11. Intake of supplemental calcium \>500 mg/day or vitamin D \>40 µg/day (1600 IU) from all sources, including diet and supplements 12. Use of medications that may interact with or impair absorption of milk products (e.g., tetracyclines) 13. Any other condition deemed by PI that may compromise participant safety and study compliance.

Where it's running

• MD11 Clinical Research Centre, #03-01, 10 Medical Drive
  Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Prof. Andrea Britta Maier, MD, PHD, FRACP — National University of Singapore
• Study coordinator: Mazzarine Dotou, PhD
• Email: mazzarine@nus.edu.sg
• Phone: +65 87264704

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.