Swiss follow-up of revision surgeries for infected joint replacements
Swiss Revision Cohort: a Nationwide, Multi-center, Prospective Periprosthetic Joint Infection Cohort Study
This project follows adults who have revision surgery for infected hip, knee, shoulder, elbow or ankle replacements to see which patient factors, bacteria, surgeries, and antibiotics are linked to cure.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 329 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Insel Gruppe AG, University Hospital Bern Academic / other |
| Locations | 5 sites (Aarau and 4 other locations) |
| Trial ID | NCT07473089 on ClinicalTrials.gov |
What this trial studies
This is a national, multicenter, prospective observational cohort enrolling adults who undergo revision surgery for suspected or confirmed periprosthetic joint infection. Clinical presentation, microbiology, surgical approaches, antibiotic regimens, and functional outcomes are collected repeatedly over time to document cure rates and complications. The study leverages standardized case definitions (European Bone and Joint Infection Society criteria) and includes patients treated at participating Swiss centers, including referrals from other hospitals when prior data are available. Data will be used to describe epidemiology, clinical phenotypes, management strategies, and outcomes, and to identify factors associated with higher or lower likelihood of infection cure.
Who should consider this trial
Good fit: Adults (18+) who undergo revision surgery for a suspected or confirmed periprosthetic joint infection at a participating Swiss center and who give written consent are ideal candidates.
Not a fit: Patients who are treated and followed up entirely outside Switzerland or whose PJI diagnosis is judged unlikely by ESBJI criteria are unlikely to benefit from this cohort.
Why it matters
Potential benefit: If successful, the study could identify treatment patterns and patient factors that lead to higher cure rates, helping clinicians make better-informed care decisions.
How similar studies have performed: Previous observational work suggests that multidisciplinary team management can improve diagnostics and outcomes for PJI, but randomized trial data comparing specific interventions remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ≥18 years of age * Revision surgery of any large prosthetic joint (i.e., hip, knee, shoulder, ankle, or elbow) performed for a suspected or confirmed periprosthetic joint infections at any of the participating study centres. This includes patients who were previously treated at another hospital and referred to a participating study centre if data on a transferred patient from the previous institution are available, complete, and archived in the institutional patient information system, and the patient underwent at least one surgery at a participating institution. * Obtained written informed consent * Periprosthetic joint infections diagnosis likely or confirmed according to European Bone and Joint Infection Society criteria Exclusion Criteria: * Documented objection to subsequent use of personal health data * Patient follow-up outside of Switzerland * Diagnosis "periprosthetic joint infections unlikely" according to European Bone and Joint Infection Society criteria
Where this trial is running
Aarau and 4 other locations
- Department of Infectious Diseases and Infection Prevention, Cantonal Hospital Aarau — Aarau, Switzerland (Recruiting)
- Department of Infectious Diseases, Bern University Hospital — Bern, Switzerland (Recruiting)
- Department of Medicine, HFR Fribourg-Hôpital Cantonal — Fribourg, Switzerland (Recruiting)
- Orthopedic Surgery Service, Geneva University Hospitals — Geneva, Switzerland (Recruiting)
- Department of Medicine, Lausanne University Hospital — Lausanne, Switzerland (Recruiting)
Study contacts
- Principal investigator: Nora Renz — Inselspital, Universitätsspital Bern
- Study coordinator: Nora Renz
- Email: nora.renz@insel.ch
- Phone: +41316322111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.