Swiss follow-up of revision surgeries for infected joint replacements
Official title: Swiss Revision Cohort: a Nationwide, Multi-center, Prospective Periprosthetic Joint Infection Cohort Study
Run by Insel Gruppe AG, University Hospital Bern · NCT07473089 · Data updated 2026-11-12
This project follows adults who have revision surgery for infected hip, knee, shoulder, elbow or ankle replacements to see which patient factors, bacteria, surgeries, and antibiotics are linked to cure.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 329 (estimated) |
| Sponsor | Insel Gruppe AG, University Hospital Bern Academic / other |
| Locations | 5 sites (Aarau and 4 other locations) |
| Status | Recruiting |
| Started | September 23, 2022 |
| Main results expected | January 2030 |
| Study ends | January 2030 |
| Registry record updated | March 16, 2026 |
| Trial ID | NCT07473089 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) who undergo revision surgery for a suspected or confirmed periprosthetic joint infection at a participating Swiss center and who give written consent are ideal candidates.
✕Probably not a fit
Patients who are treated and followed up entirely outside Switzerland or whose PJI diagnosis is judged unlikely by ESBJI criteria are unlikely to benefit from this cohort.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a national, multicenter, prospective observational cohort enrolling adults who undergo revision surgery for suspected or confirmed periprosthetic joint infection. Clinical presentation, microbiology, surgical approaches, antibiotic regimens, and functional outcomes are collected repeatedly over time to document cure rates and complications. The study leverages standardized case definitions (European Bone and Joint Infection Society criteria) and includes patients treated at participating Swiss centers, including referrals from other hospitals when prior data are available. Data will be used to describe epidemiology, clinical phenotypes, management strategies, and outcomes, and to identify factors associated with higher or lower likelihood of infection cure.
Why it matters
Potential benefit: If successful, the study could identify treatment patterns and patient factors that lead to higher cure rates, helping clinicians make better-informed care decisions.
How similar studies have gone: Previous observational work suggests that multidisciplinary team management can improve diagnostics and outcomes for PJI, but randomized trial data comparing specific interventions remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ≥18 years of age * Revision surgery of any large prosthetic joint (i.e., hip, knee, shoulder, ankle, or elbow) performed for a suspected or confirmed periprosthetic joint infections at any of the participating study centres. This includes patients who were previously treated at another hospital and referred to a participating study centre if data on a transferred patient from the previous institution are available, complete, and archived in the institutional patient information system, and the patient underwent at least one surgery at a participating institution. * Obtained written informed consent * Periprosthetic joint infections diagnosis likely or confirmed according to European Bone and Joint Infection Society criteria Exclusion Criteria: * Documented objection to subsequent use of personal health data * Patient follow-up outside of Switzerland * Diagnosis "periprosthetic joint infections unlikely" according to European Bone and Joint Infection Society criteria
Where it's running
-
Department of Infectious Diseases and Infection Prevention, Cantonal Hospital Aarau
Aarau, Switzerland Recruiting -
Department of Infectious Diseases, Bern University Hospital
Bern, Switzerland Recruiting -
Department of Medicine, HFR Fribourg-Hôpital Cantonal
Fribourg, Switzerland Recruiting -
Orthopedic Surgery Service, Geneva University Hospitals
Geneva, Switzerland Recruiting -
Department of Medicine, Lausanne University Hospital
Lausanne, Switzerland Recruiting
Study contacts
- Principal investigator: Nora Renz — Inselspital, Universitätsspital Bern
- Study coordinator: Nora Renz
- Email: nora.renz@insel.ch
- Phone: +41316322111
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Virtual Reality Therapy to Improve Arthroplasty Outcomes
This pilot test checks whether using virtual reality during the perioperative period helps knee or hip replacement patients feel better about their care and recover more easily.
-
CBP-0276 added to standard opioid therapy after hip or knee replacement
This Phase 2 trial tests whether CBP-0276 taken daily for 28 days can reduce the number of opioid tablets adults need after hip or knee replacement.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.