Sweet almonds to help heal femur and tibia shaft fractures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults (18–55) with trauma-associated femur or tibia shaft fractures presenting to Aga Khan University Hospital will receive Prunus dulcis (sweet almonds) as an intervention and be followed during their healing period. Fracture repair will be monitored using radiographic measures such as callus formation, callus bridging, and callus index, together with clinical assessments and safety monitoring. Patients already on bone-strengthening drugs, with severe cardiovascular/hepatic/renal disease, or with known almond allergy are excluded. The trial seeks to determine whether almonds offer a feasible, low-cost adjunct to support bone healing with acceptable safety.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients of 18 to 55 years of age of any gender.
2. Agree and able to voluntary participate.
3. Patients with trauma associated femur fracture and tibia shaft fracture arriving at hospital for treatment.

Exclusion Criteria:

1. Mentally retarded or patients with severe psychiatric illness.
2. Patients are already on bone-strengthening drugs (bisphosphonates, vitamin D, strontium ranelate, teriparatide, etc.).
3. Patients who require bone-strengthening drugs for osteoporosis or for any urgent need.
4. Severe cardiovascular, hepatic, or renal disease.
5. Known allergy or toxicity to Prunus dulcis (almonds) and/or vitamin D supplements.

Where it's running

• The Aga Khan University
  Karachi, Pakistan Recruiting

Study contacts

• Principal investigator: Zehra A Muhammad, M.B.B.S., M.S. Research — Aga Khan University
• Study coordinator: Zehra A Muhammad, M.B.B.S., M.S. Research
• Email: zehra.abdul@aku.edu
• Phone: +92 21 54864746

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.