Suture mucopexy plus laser treatment for moderate-to-severe hemorrhoids
Official title: Prospective Evaluation of Hemorrhoid Suture Mucopexy (SM) Combined With Laser Hemorrhoidoplasty (LHP) for Symptomatic Hemorrhoidal Disease: A Cohort Study
Run by National and Kapodistrian University of Athens · NCT07404774 · Data updated 2026-11-12
This study will test whether adding a stitch-based mucosal lift to laser hemorrhoidoplasty reduces pain, bleeding, and prolapse in adults with moderate-to-severe (Grade II–IV) hemorrhoids.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | National and Kapodistrian University of Athens Academic / other |
| Locations | 1 site (Athens) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | January 2028 |
| Study ends | January 2029 |
| Registry record updated | February 11, 2026 |
| Trial ID | NCT07404774 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with symptomatic hemorrhoidal disease (Goligher Grades II–IV), including those with prior non-stapled procedures, who can attend the Athens center are ideal candidates.
✕Probably not a fit
Patients with acutely thrombosed hemorrhoids, concurrent anal fistula or abscess requiring separate surgery, active rectal IBD, or prior stapled haemorrhoidopexy are excluded and unlikely to benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center, prospective observational cohort in which all enrolled adults with Goligher Grade II–IV hemorrhoids receive a combined suture mucopexy and non‑Doppler laser hemorrhoidoplasty. The combined procedure aims to remove mucosal prolapse and ligate feeding vessels while preserving the low-pain recovery profile of laser treatment. Participants are followed at 6 weeks, 6 months, and 12 months to record pain medication use, time to complete symptom relief, quality of life, safety events (bleeding, urinary retention, stenosis), and recurrence or re-operation. The approach is supported by preliminary feasibility data from 50 patients at the same center but is being evaluated formally in this prospective cohort.
Why it matters
Potential benefit: If successful, the combined technique could give faster symptom relief with fewer recurrences and fewer repeat operations while maintaining low post‑operative pain.
How similar studies have gone: Laser hemorrhoidoplasty is known for low‑pain recovery but higher recurrence in advanced prolapse, and single-center preliminary data (50 patients) suggest the mucopexy+LHP combination is feasible with low early complications, though larger prospective evidence is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (\>18 years). * Symptomatic Hemorrhoidal Disease (Goligher Grades II, III, IV). * Patients with or without recurrent disease after prior procedures (e.g., RBL, infrared coagulation, Milligan-Morgan, etc). Exclusion Criteria: * Acutely thrombosed hemorrhoids. * Concomitant anal fistula or abscess requiring separate surgical management. * IBD (Crohn's/Ulcerative Colitis) with active rectal involvement. * Previous Stapled Haemorrhoidopexy (SH/Longo).
Where it's running
-
Ippokrateio Hospital
Athens, Greece Recruiting
Study contacts
- Study coordinator: George Theodoropoulos
- Email: georgetheocrs@live.com
- Phone: +30 213 208.8000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.