Surgical treatment for idiopathic rhinitis using nerve procedures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of a surgical approach combining posterior nasal nerve neurotomy with anterior ethmoid neurotomy for patients suffering from idiopathic rhinitis. Participants are randomized into two groups: one receiving the surgical intervention and the other receiving conventional drug therapy. The study includes a 7-day introductory period with nasal spray treatment before randomization, followed by a one-year follow-up to assess outcomes. The goal is to determine if the surgical method provides better relief from symptoms compared to medication alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients signed the free and informed consent form and understood the explanation of the study.
2. patients with IR between 18 and 65 years and their body mass index (BMI) should be ≥19 kg/m2 and ≤24 kg/m2.
3. Patients diagnosed with idiopathic rhinitis （IR）that were defined as nonsmoking patients with at least 2 nasal complaints of nasal obstruction, rhinorrhea, itching, and/or sneezing for more than 1 hour a day and for more than 1 year.
4. Patients with negative skin prick test (SPT) responses or sIgE
5. Nasal cytological exam with eosinophilia less than 20%.
6. Patients had a Total Nasal Symptom Score (TNSS) of ≥6 and a subscore of nasal discharge ≥2 and a subscore of nasal congestion ≥1.

Exclusion Criteria:

1. Patients with colored secretions, inflammation，nasal polyps, chronic sinusitis, nasal tumours.
2. Patients with other chronic rhinitis such as occupational rhinitis, drug rhinitis, gustatory rhinitis, hormonal rhinitis, atrophic rhinitis, etc.
3. Patients with anatomic nasal abnormalities responsible for nasal symptoms.
4. Patients with nasal/sinus surgery 3 months before the study.
5. Patients with severe mental illness.
6. Patients with uncontrolled asthma, systemic disorders or malignancies.
7. Patients with history of chronic smoking, substance abuse, drug use, and/or excessive alcohol consumption.
8. Patients in pregnancy or lactation.

Where it's running

• Renmin Hospital of Wuhan University
  Wuhan, Hubei, China Recruiting
• Renmin Hospital of Wuhan University
  Wuhan, Hubei, China Not yet recruiting

Study contacts

• Study coordinator: Yu Xu
• Email: xuy@whu.edu.cn
• Phone: +8615927088198

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.