Surgical procedures for chronic rhinosinusitis with nasal polyps
Subjective and Objective Outcom Eof Endoscopic Sinus Surgery in Patients With Chronic Rhinosinusitis With Nasal Polyps
This study tests which surgical technique works better for people with chronic rhinosinusitis and nasal polyps who haven't found relief from other treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 99 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University of Zurich Academic / other |
| Locations | 1 site (Zurich) |
| Trial ID | NCT04868695 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the outcomes of different surgical techniques for patients suffering from chronic rhinosinusitis with nasal polyps (CRSwNP) who have not responded to conservative treatments. The study compares the effectiveness of Fronto-Sphenoethmoidektomie procedures, specifically Draf Type II and Type III, in alleviating symptoms and improving nasal function. Patients will undergo these surgical interventions to assess both subjective and objective outcomes post-surgery. The trial aims to provide insights into the best surgical approaches for managing CRSwNP.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18-65 with symptomatic CRSwNP who have not experienced improvement after at least six months of conservative treatment.
Not a fit: Patients who have previously undergone sinus surgery or have other significant sinus pathologies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical techniques that significantly enhance the quality of life for patients with chronic rhinosinusitis.
How similar studies have performed: Other studies have shown promising results with similar surgical approaches for CRSwNP, indicating potential for success in this trial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Symptomatic CRSwNP patients without improvement after conservative treatment for at least 6 months Extent of disease at least Davos Polyp Score ≥ 4 points Age 18-65 years Signed consent Exclusion Criteria: * Previous sinunasal surgery High resolution paranasal sinus CT shows other pathology (e.g. mucocele) Incapable of judgement
Where this trial is running
Zurich
- Zurich University Hospital — Zurich, Switzerland (Recruiting)
Study contacts
- Study coordinator: Michael B Soyka, MD
- Email: rhinologie@usz.ch
- Phone: 0432531460
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.